Synthesis of tri-substituted allyl alcohols via a copper/iron co-catalyzed cascade perfluoroalkylation/rearrangement of aryl propynyl ethers
文献信息
发布日期
2019-09-05
DOI
10.1039/C9QO00848A
影响因子
5.281
作者
Wei He, Jipan Yu, Dawei Wang, Guoxia Ran, Xiao-Feng Xia
查看原文
摘要
A copper/iron co-catalyzed fluoroalkylative cascade cyclization/1,4-aryl migration of aryl propynyl ethers with readily available iodoperfluoroalkane reagents for the synthesis of the corresponding perfluoroalkylated tri-substituted allyl alcohol derivatives is reported. This novel protocol provides a very mild method for the construction of perfluoroalkylated cinnamyl alcohols in one step with high regio- and stereo-selectivities. Further efficient application of this protocol is illustrated with the synthesis of 2-perfluoroalkyl-3-aryl-1H-indenes via a simple acidic workup.
期刊推荐
Current Opinion in Solid State & Materials Science
Russian Journal of Bioorganic Chemistry
Chemical Communications
Acta Materialia
Journal of Saudi Chemical Society
Saudi Pharmaceutical Journal
Journal of Natural Medicines
Russian Journal of Applied Chemistry
Chemistry Education Research and Practice
Russian Journal of General Chemistry
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来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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