Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition
文献信息
发布日期
2019-10-09
DOI
10.1039/C9QO01046G
影响因子
5.281
作者
Da-Peng Qin, Qian-Qian Di, Ying Liu, Wei-Lin Chen, Shu-Mei Wang, Yong-Xian Cheng
查看原文
摘要
Commiphorines A (1), an unprecedented sesquiterpenoid heterodimer featuring a 5/7(5)/4/10/5 ring system, and B (2), a dimeric sesquiterpenoid possessing an unusual 1,4-dioxin motif and a 6/6/5/6/6/6 polycyclic system, and two intermediates 3 and 4 were isolated from Resina Commiphora. A plausible biosynthetic route for 1 and 2 was proposed. Compound 2 could significantly suppress LPS-induced inflammation through NF-κB and MAPK signaling pathways in mouse peritoneal macrophages. Compounds 1 and 2 could inhibit lipid synthesis in HepG2 cells.
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来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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