Transition-metal free direct C–H functionalization of quinoxalin-2(1H)-ones with oxamic acids leading to 3-carbamoyl quinoxalin-2(1H)-ones

文献信息

发布日期 2019-11-27

DOI 10.1039/C9QO01322A

影响因子 5.281

作者

Jin-Wei Yuan, Jun-Liang Zhu, Hu-Lin Zhu, Fang Peng, Liang-Yu Yang, Pu Mao, Shou-Ren Zhang, Yan-Chun Li, Ling-Bo Qu

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摘要

A practical transition-metal free decarboxylative coupling reaction of oxamic acids with quinoxalin-2(1H)-ones has been developed under mild conditions. This transformation provides an efficient approach for the preparation of 3-carbamoyl quinoxalin-2(1H)-ones, which are important subunits in biologically active natural products and medicinal chemistry. This protocol features broad substrate scope, good yields, and mild reaction conditions.

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Russian Chemical Bulletin

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来源期刊

Organic Chemistry Frontiers

CiteScore: 7.8

自引率: 8.7%

年发文量: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Transition-metal free direct C–H functionalization of quinoxalin-2(1H)-ones with oxamic acids leading to 3-carbamoyl quinoxalin-2(1H)-ones

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Organic Chemistry Frontiers

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