Polymersome formation induced by encapsulation of water-insoluble molecules within ABC triblock terpolymers

文献信息

发布日期 2020-04-21

DOI 10.1039/D0PY00426J

影响因子 5.582

作者

Rintaro Takahashi, Shotaro Miwa, Carsten Rössel, Shota Fujii, Ji Ha Lee, Kazuo Sakurai

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摘要

Polymeric micelles have been extensively studied as nanoscale drug carriers. Knowing how the encapsulation of drugs alters the micellar structure is one of the most important issues for the biomedical application of amphiphilic block copolymers. However, little is known so far about the structural changes that micelles undergo upon loading with water-insoluble guests. Herein, we investigate the micellar morphology of ABC triblock terpolymers after loading with various water-insoluble molecules (naphthalene and its derivatives as drug-equivalent model molecules). The triblock terpolymer features a poly(ethylene oxide) (PEO) block, a poly(allyl glycidyl ether) segment which has been functionalized with carboxylic acid moieties (PAGECOOH), and poly(tert-butyl glycidyl ether) (PtBGE) as a hydrophobic block. Structural analysis by small-angle X-ray scattering (SAXS) and cryogenic and conventional transmission electron microscopy (TEM) found that a morphological transition from spherical micelles to vesicles (polymersomes) was induced by loading the guest molecules at pH 4, whilst the spherical and prolate morphologies remained unchanged upon loading at pH 6 and 8. This study highlights the dynamics and morphological changes of polymeric micelles upon loading with guest molecules.

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Medicinal Chemistry Research

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来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Polymersome formation induced by encapsulation of water-insoluble molecules within ABC triblock terpolymers

文献信息

期刊推荐

相关文献

Recent advances in the development of covalent inhibitors

Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance

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Synthesis and biological evaluation of a monocyclic Fc-binding antibody-recruiting molecule for cancer immunotherapy

Inside front cover

N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa

Back cover

Cucurbit[8]uril-based supramolecular hydrogels for biomedical applications

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