Recent advances in the synthesis of bridgehead (or ring-junction) nitrogen heterocycles via transition metal-catalyzed C–H bond activation and functionalization
文献信息
发布日期
2020-08-05
DOI
10.1039/D0QO00510J
影响因子
5.281
作者
Biao Nie, Wanqing Wu, Yingjun Zhang, Huanfeng Jiang, Ji Zhang
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摘要
Bridgehead nitrogen (or ring-junction nitrogen) heterocycles are one of the most privileged scaffolds in synthetic chemistry and medicinal chemistry. For decades, transition metal-catalyzed C–H activation has provided straightforward access to bridgehead nitrogen heterocycles in an atom-economical manner. Palladium, rhodium, ruthenium, iridium, cobalt, nickel, silver, and copper catalysts were used for the successful synthesis of these skeletons. Herein, we summarize recent advances that are made in the synthesis of bridgehead nitrogen heterocycles via diverse transition metal-catalyzed C–H activations and C–H functionalizations. This review covers the period from May 2004 to April 2020.
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来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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