![(3S,4aS,8aS)-2-[(2R,3S)-3-Amino-2-hydroxy-4-phenylbutyl]-N-(2-methyl-2-propanyl)decahydro-3-isoquinolinecarboxamide structure](https://cnstatic.chemtradehub.com/structs/136/136522-17-3-4d77.webp "(3S,4aS,8aS)-2-[(2R,3S)-3-Amino-2-hydroxy-4-phenylbutyl]-N-(2-methyl-2-propanyl)decahydro-3-isoquinolinecarboxamide structure")
Photo-induced preparation of unnatural α-amino acids: synthesis and characterization of novel Leu5-enkephalin analogues
文献信息
发布日期
2020-07-28
DOI
10.1039/D0QO00696C
影响因子
5.281
作者
Hongxiang Xue, Mengzhun Guo, Chao Wang, Yuxuan Shen, Rupeng Qi, Yifei Wu, Zhaoqing Xu, Min Chang
查看原文
摘要
We here report the first example of the photo-induced preparation of unnatural α-amino acids and modification of peptides with unactivated alkyl chlorides (iodides) without the assistance of a transition metal catalyst or photosensitizer. The method was successfully applied for the late-stage modification of peptides and provided a novel enkephalin analogue with significantly better analgesic activity and 2.6-fold more long-lasting time compared to its parent peptide.
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来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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