An organocatalytic enantioselective ring-reorganization domino sequence of methyleneindolinones with 2-aminomalonates
文献信息
发布日期
2020-12-17
DOI
10.1039/D0QO01364A
影响因子
5.281
作者
Zhen-Zhen Xie, Lan Zheng, Zhi-Peng Ye, Zhi-Xiong Deng, Qing-Lan Zhao, Jun-An Xiao, Kai Chen, Hao-Yue Xiang, Xiao-Qing Chen, Hua Yang
查看原文
摘要
An organocatalytic enantioselective ring-reorganization domino sequence (Michael addition/intramolecular ring-opening/lactamization) of methyleneindolinones with 2-aminomalonates has been established in this work. As a result, pyrrolo[3,4-c]quinolinones bearing two to three contiguous chiral centers were efficiently assembled in high yields (up to 92%) with excellent diastereoselectivities (>20 : 1 dr) and enantioselectivities (up to >99% ee).
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来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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