A mimotope attached to an ITIM–SHP-1 interaction inhibitory peptide boosts immune response and efficacy
文献信息
Koushik Roy, Syamal Roy, Siddhartha Roy
Antigen binding to the B-cell receptor initiates a downstream signalling pathway that contains both stimulatory and damping components. A malarial parasite-derived conformation-constrained peptide was conjugated to a signal-damping pathway inhibitor. Mice immunized with this antigen produced higher antibody levels which delayed parasitemia. This represents a new approach to antigen design.
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