Medicinal chemistry of the myeloid C-type lectin receptors Mincle, Langerin, and DC-SIGN
文献信息
Jonathan Cramer
In their role as pattern-recognition receptors on cells of the innate immune system, myeloid C-type lectin receptors (CLRs) assume important biological functions related to immunity, homeostasis, and cancer. As such, this family of receptors represents an appealing target for therapeutic interventions for modulating the outcome of many pathological processes, in particular related to infectious diseases. This review summarizes the current state of research into glycomimetic or drug-like small molecule ligands for the CLRs Mincle, Langerin, and DC-SIGN, which have potential therapeutic applications in vaccine research and anti-infective therapy.
期刊推荐

Science Progress

Journal of Heterocyclic Chemistry

Journal of Medicinal Chemistry

Israel Journal of Chemistry

Pharmacological Reviews

Pure and Applied Chemistry

Proceedings of the National Academy of Sciences of the United States of America

Kinetics and Catalysis

Fibre Chemistry

European Journal of Wood and Wood Products
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