SAR study of 4-arylazo-3,5-diamino-1H-pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms

文献信息

发布日期 2021-09-03

DOI 10.1039/D1MD00275A

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作者

Charlotte U. Jansen, Jesper Uhd, Jens B. Andersen, Louise D. Hultqvist, Tim H. Jakobsen, Martin Nilsson, Michael Givskov, Tim Tolker-Nielsen, Katrine M. Qvortrup

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摘要

By screening of a collection of 50 000 small-molecule compounds, we recently identified 4-arylazo-3,5-diamino-1H-pyrazoles as a novel group of anti-biofilm agents. Here, we report a SAR study based on 60 analogues by examining ways in which the pharmacophore can be further optimized, for example, via substitutions in the aryl ring. The SAR study revealed the very potent anti-biofilm compound 4-(2-(2-fluorophenyl)hydrazineylidene)-5-imino-4,5-dihydro-1H-pyrazol-3-amine (2).

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来源期刊

RSC Medicinal Chemistry

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自引率: 0%

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SAR study of 4-arylazo-3,5-diamino-1H-pyrazoles: identification of small molecules that induce dispersal of Pseudomonas aeruginosa biofilms

文献信息

期刊推荐

相关文献

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Front cover

Competitive adsorption on gold nanoparticles for human papillomavirus 16 L1 protein detection by LDI-MS

Biosensor surface functionalization by a simple photochemical immobilization of antibodies: experimental characterization by mass spectrometry and surface enhanced Raman spectroscopy

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来源期刊

RSC Medicinal Chemistry

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