Photo cleavable thioacetal block copolymers for controlled release

文献信息

发布日期 2021-06-08

DOI 10.1039/D1PY00514F

影响因子 5.582

作者

Yongjun Men, Tobias G. Brevé, Antonia G. Denkova, Rienk Eelkema

查看原文

摘要

We present a new light cleavable polymer containing o-nitrobenzene thioacetal groups in the main chain. By conjugation to a PEG block, we synthesized block copolymers capable of forming nanoparticles in aqueous solution. We studied drug encapsulation and release using the model drug Nile Red. Irradiation with UV-A light (365 nm) leads to efficient degradation of the polymers and associated burst release of the payload. Unlike other thioacetal and thioketal polymers, these polymers are stable to reactive oxygen species (ROS), preventing non-triggered release. Moreover, the nanocarriers showed low cytotoxicity in cell viability experiments.

期刊推荐

European Journal of Organic Chemistry

Coloration Technology

Contact Lens & Anterior Eye

Angewandte Chemie International Edition

Environmental Toxicology and Pharmacology

Advanced Engineering Materials

Lab on a Chip

Foundations of Chemistry

Molecular Diversity

Mini-Reviews in Medicinal Chemistry

来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Photo cleavable thioacetal block copolymers for controlled release

文献信息

期刊推荐

相关文献

Potential energy surfaces of a stacked dimer of benzene and its radical cation: what remains and what appears

Critical size effect for the surface heat capacities of nano-CdS: theoretical and experimental studies

Impact of Bi doping on nonradiative carrier recombination in CsPbI3

Multiple-cation wide-bandgap perovskite solar cells grown using cesium formate as the Cs precursor with high efficiency under sunlight and indoor illumination

Choline chloride and ethylene glycol based deep eutectic solvent (DES) versus hydroxyl functionalized room temperature ionic liquids (RTILs): assessing the differences in microscopic behaviour between the DES and RTILs

Unraveling the multivalent aluminium-ion redox mechanism in 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA)

Contents list

Mechanical stimulation of energetic materials at the nanoscale

Collision-assisted stripping for determination of microsolvation-dependent protonation sites in hydrated clusters by cryogenic ion trap infrared spectroscopy: the case of benzocaineH+(H2O)n‡

Template-free synthesis of Bi2O2CO3 hierarchical nanotubes self-assembled from ordered nanoplates for promising photocatalytic applications

您可能还喜欢

什么是2,6-二溴-4,8-双[(2-乙基己基)氧基]苯并[1,2-b:4,5-b']二噻吩(CAS号：1226782-13-3)？

木聚硫钠(CAS号：37319-17-8)的物理化学性质是什么？

2-甲氧基-4-(三氟甲基)苄溴, JRD(CAS号：886500-59-0)适用哪些法规指南？

1,4-Diazoniabicyclo[2.2.2]octane-1,4-disulfinate(CAS号：119752-83-9)的主要用途是什么？

如何处理含有4-(Bromomethyl)-2-fluorobenzenesulphonamide(CAS号：1645275-47-3)的废料？

Loureiriol(CAS号：479195-44-3)的物理化学性质是什么？

在合成中是否有3-氨基苯甲酰苯胺(CAS号：14315-16-3)的替代品？

4-异氰酰苯基硼酸频哪醇酯(CAS号：380430-64-8)的市场或研究趋势如何？

如何储存3β-乙酰氧基-7,25-甘遂二烯-24(R)-醇(CAS号：1352001-09-2)？

如何储存4-氟-2-甲基-1H-吲哚(CAS号：1260383-51-4)？

来源期刊

Polymer Chemistry

推荐化合物

4-Bromo-1-methyl-1H-benzotriazole

Xanthosine; 5'-Triphosphate

8-Methoxy-1,3-dihydro-2H-3-benzazepin-2-one

Ethyl 4-[8-chloro(5,5,6,6,7-~2~H_5_)-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidinecarboxylate

4-Methyl-2-oxo-2H-chromen-7-yl 2-acetamido-2-deoxy-3-O-(6-deoxy-alpha-L-galactopyranosyl)-beta-D-glucopyranoside

推荐供应商