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Polymer based nanoparticles for biomedical applications by microfluidic techniques: from design to biological evaluation
文献信息
发布日期
2021-10-19
DOI
10.1039/D1PY01077H
影响因子
5.582
作者
Antonio Fabozzi, Francesca Della Sala, Mario di Gennaro, Nicola Solimando, Maurizio Pagliuca, Assunta Borzacchiello
查看原文
摘要
The development of microfluidic technologies represents a new strategy to produce and test drug delivery systems. In particular, microfluidics can facilitate the development of new nanoparticle-based systems with controlled physicochemical properties and evaluate their efficiency and efficacy in in vitro biomimetic models of human organs (organ-on-a-chip). Microfluidics shows promising effective potential for the preclinical testing of nanoparticle-based drug delivery systems compared to the traditional in vitro cell culture. In this review, we present a detailed state-of-the-art based on the microfluidic technologies focusing on the synthesis, industrial scale-up, and biological characterization of polymeric nanoparticles for drug delivery applications.
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来源期刊
Polymer Chemistry
CiteScore:
8.6
自引率:
7.3%
年发文量:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
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