RhIII-Catalyzed formal [5 + 1] cyclization of 2-pyrrolyl/indolylanilines using vinylene carbonate as a C1 synthon
文献信息
发布日期
2021-02-08
DOI
10.1039/D1QO00040C
影响因子
5.281
作者
Jiang Nan, Qiong Ma, Jiacheng Yin, Chengyuan Liang, Lei Tian, Yangmin Ma
查看原文
摘要
A rhodium(III)-catalyzed formal C–H [5 + 1] cyclization of 2-pyrrolyl/indolylanilines with vinylene carbonate has been explored towards the potent assembly of diverse 4-methylpyrrolo[1,2-a]quinoxalines. This established protocol is characterized by an exceedingly simple reaction system, and excellent functional group toleration and yields. Most importantly, entirely distinct from documented [4 + 2] cyclization conversions, herein, the emerging vinylene carbonate firstly presents as a C1 synthon to realize [5 + 1] annulation and shows new chemical reactivity. Biological studies indicate that these prepared products are promising candidates in terms of their antibacterial activity.
期刊推荐
Organic Process Research & Development
Journal of Natural Medicines
Chemical Communications
Acta Materialia
Current Opinion in Solid State & Materials Science
Current Opinion in Colloid & Interface Science
Saudi Pharmaceutical Journal
Russian Journal of Bioorganic Chemistry
Journal of Peptide Science
Russian Journal of Coordination Chemistry
相关文献
Dinuclear manganese complexes for water oxidation: evaluation of electronic effects and catalytic activity
Wael A. A. Arafa, Markus D. Kärkäs, Bao-Lin Lee, Torbjörn Åkermark, Rong-Zhen Liao, Hans-Martin Berends, Johannes Messinger, Per E. M. Siegbahn, Björn Åkermark
2014-01-27
Paper
DOI: 10.1039/C3CP54800G
A first-principle investigation of double-side CVD catalyst metal/graphene contacts
Xiang Ji, Yan Wang, Zhiping Yu
2014-03-25
Paper
DOI: 10.1039/C4CP00960F
Electrical conductivity and glass formation in nitrile-functionalized pyrrolidinium bis(trifluoromethylsulfonyl)imide ionic liquids: chain length and odd–even effects of the alkyl spacer between the pyrrolidinium ring and the nitrile group
Jan Leys, Chandra Shekhar Pati Tripathi, Christ Glorieux, Stefan Zahn, Barbara Kirchner, Stéphane Longuemart, Kallidanthiyil Chellappan Lethesh, Peter Nockemann, Wim Dehaen, Koen Binnemans
2014-03-24
Paper
DOI: 10.1039/C4CP00259H
An acetate bound cobalt oxide catalyst for water oxidation: role of monovalent anions and cations in lowering overpotential
Subal Dey, Biswajit Mondal, Abhishek Dey
2014-04-11
Paper
DOI: 10.1039/C4CP01205D
Theoretical study of thermoelectric properties of few-layer MoS2 and WSe2
Wen Huang, Chee Kwan Gan, Gengchiau Liang
2014-04-14
Paper
DOI: 10.1039/C4CP00487F
Dynamic control of Förster energy transfer in a photonic environment
Frank Schleifenbaum, Andreas M. Kern, Alexander Konrad, Alfred J. Meixner
2014-05-01
Paper
DOI: 10.1039/C4CP01306A
Excitonic energy transfer in polymer wrapped carbon nanotubes in gradually grown nanoassemblies
Victor A. Karachevtsev, Alexander M. Plokhotnichenko, Victor S. Leontiev
2014-04-14
Paper
DOI: 10.1039/C4CP00776J
Experimental determination of electrostatic properties of Na–X zeolite from high resolution X-ray diffraction
2014-03-31
Paper
DOI: 10.1039/C3CP55397C
Confined H2O molecules as local probes of pressure-induced amorphisation in faujasite
Frederico Alabarse, Claire Levelut, Aude Isambert, Philippe Hébert, Shinji Kohara, David Maurin, Jean-Louis Bantignies, Olivier Cambon, Gaëlle Creff, Pascale Roy, Jean-Blaise Brubach, Tahar Hammouda, Denis Andrault, Julien Haines
2014-04-28
Paper
DOI: 10.1039/C4CP00186A
您可能还喜欢
化合物问答
十二烷基磺酸钠(CAS号：2386-53-0)的主要用途是什么？
十二烷基磺酸钠主要用作表面活性剂，广泛应用于洗涤剂、肥皂、化妆品和工业清洁产品中。它能有效去除油脂和污垢，常用于制造洗发水、沐浴露、洗衣粉和金属清洗剂。此外，它...
2386-53-01-Dodecanesulfonic a...
化合物问答
5-羟基异喹啉(CAS号：2439-04-5)适用哪些法规指南？
5-羟基异喹啉作为化学品，主要适用的法规包括GHS全球化学品统一分类和标签制度，REACH法规等。GHS将5-羟基异喹啉分类为皮肤腐蚀/刺激类别2，严重眼损伤/...
2439-04-55-Isoquinolinol
化合物问答
在合成中是否有FIDAS-5 | Wnt(CAS号：1391934-98-7)的替代品？
合成中可以考虑使用类似结构的化合物，如4-[(E)-2-(2-氯-6-氟苯基)乙烯基]-N-甲基苯胺的类似物或衍生物作为替代品。这类化合物可能具有相似的生物活性...
1391934-98-74-[(E)-2-(2-Chloro-6...
化合物问答
(R)-tert-Butyl 2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylate(CAS号：1370600-56-8)通常如何合成？
该化合物通常通过如下步骤合成：首先，将4-溴-1H-咪唑与对甲苯磺酸在乙酸乙酯中反应，得到中间体5-溴-1H-咪唑-2-甲酸乙酯。然后，该中间体与2-甲基-2-...
1370600-56-82-Methyl-2-propanyl ...
化合物问答
处理4-(吡咯烷-1-基)环己酮(CAS号：10421-18-8)时应注意哪些实验室安全事项？
处理4-(吡咯烷-1-基)环己酮时，应佩戴手套、护目镜和实验室外套，以防止直接接触或吸入。在通风橱中操作，确保良好的通风条件。一旦发生泄漏，应立即清理并使用适当...
10421-18-84-(Pyrrolidin-1-yl)c...
化合物问答
如何处理含有异麦芽糖醇(CAS号：534-73-6)的废料？
含有异麦芽糖醇的废液应首先进行分类收集，避免与其他化学品混合。对于小规模的废液，可以通过焚烧或加入特定的化学试剂进行无害化处理。对于大规模的废液，建议联系专业的...
534-73-66-O-alpha-D-Glucopyr...
化合物问答
7-甲基壬酸(CAS号：41653-89-8)的主要用途是什么？
7-甲基壬酸主要用于有机合成领域，作为合成其他化合物的原料。此外，它还可能作为一种中间体用于药品制造和香料合成，但具体用途需要根据其具体的化学结构和反应特性来确...
41653-89-87-Methylnonanoic aci...
化合物问答
N-甲氧基-N-甲基甲基吡啶羧酰胺(CAS号：148493-07-6)应用于哪些行业？
N-甲氧基-N-甲基甲基吡啶羧酰胺在医药领域有一定的应用，作为一种潜在的药物前体或中间体。此外，该化合物也可能应用于聚合物改性剂、传感器材料等。由于其独特的化学...
148493-07-6N-Methoxy-N-methylpi...
化合物问答
什么是惕各酸香叶酯(CAS号：7785-33-3)？
惕各酸香叶酯是一种化合物，化学名称为(2E)-3,7-二甲基-2,6-辛二烯-1-基(2E)-2-甲基-2-丁烯酸酯。它是一种具有香叶香气的化合物，分子式为C1...
7785-33-3(2E)-3,7-Dimethyl-2,...
化合物问答
1-环丁基哌嗪(CAS号：132800-13-6)安全吗？
1-环丁基哌嗪在适当的操作条件下是相对安全的，但如遇明火或高热会释放有毒气体。操作时应佩戴防护眼镜和手套，避免吸入或接触皮肤、眼睛。
132800-13-61-Cyclobutylpiperazi...
来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
推荐化合物
![4-[2-(Trichlorosilyl)ethyl]benzenesulfonyl chloride structure](https://cnstatic.chemtradehub.com/structs/797/79793-00-3-de16.webp "4-[2-(Trichlorosilyl)ethyl]benzenesulfonyl chloride structure")
推荐供应商
免责声明
本页面提供的学术期刊信息仅供参考和研究使用。我们与任何期刊出版商均无关联，也不处理投稿事宜。如有投稿相关咨询，请直接联系相关期刊出版商。
如发现页面信息有误，请发送邮件至 support@chemtradehub.com 联系我们。我们将及时核实并处理您的问题。