Tandem Strecker/C(sp3)–H amination reactions for the construction of cyanide-functionalized imidazo[1,5-a]pyridines with NH4SCN as a cyanating agent

文献信息

发布日期 2021-09-21

DOI 10.1039/D1QO01060C

影响因子 5.281

作者

Xiao-Tong Yan, De-Xiang Chen, Zhong-Zhong Yan, Kun Xu

查看原文

摘要

An I2O5 promoted tandem Strecker/C(sp3)–H amination reaction of pyridine-2-carboxaldehydes, benzylamines and NH4SCN has been reported. This multicomponent reaction that allows the single-step construction of biologically important cyano-functionalized imidazo[1,5-a]pyridines with molecular diversity was realized for the first time. Moreover, the use of safe and easy-to-handle NH4SCN as a surrogate cyanating agent makes this protocol appealing for potential applications.

期刊推荐

Proceedings of the National Academy of Sciences of the United States of America

Organic Preparations and Procedures International

Molecular Pharmacology

Russian Chemical Reviews

Planta Medica

Fibre Chemistry

Israel Journal of Chemistry

Pharmacological Reviews

Journal of Medicinal Chemistry

Journal of Organometallic Chemistry

来源期刊

Organic Chemistry Frontiers

CiteScore: 7.8

自引率: 8.7%

年发文量: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry