![1-[(4-Methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile structure](https://cnstatic.chemtradehub.com/structs/143/1434747-57-5-fc0d.webp "1-[(4-Methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile structure")
Ligand-accelerated site-selective Csp2–H and Csp3–H alkynylations of alcohols via Pd(ii) catalysis
文献信息
发布日期
2021-10-02
DOI
10.1039/D1QO01095F
影响因子
5.281
作者
Aidong Huang, Yishen Han, Peiqing Wu, Yang Gao, Yanping Huo, Qian Chen, Xianwei Li
查看原文
摘要
A ligand-accelerated site-selective C–H alkynylation of weakly coordinated yet synthetically promising alcohols, via putative 6, 7 and 8-membered palladacycle intermediates, was developed. The endo-type C–H activation of olefins has been previously well developed, and in the current work we developed an exo C–H alkynylation of alkenols. Importantly, by making judicious choices of amide attached oximes, challenging secondary and tertiary Csp3–H alkynylations of alcohols were also realized.
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来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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