Rh(iii)-Catalyzed C–H allylation/annulative Markovnikov addition with 5-methylene-1,3-dioxan-2-one: formation of isoquinolinones containing a C3 quaternary centre

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发布日期 2021-10-05

DOI 10.1039/D1QO01232K

影响因子 5.281

作者

Xinghua Li, Jintong Bai, Zhaoyu Huang, Minhai Yin, Jiarong Sheng

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摘要

The Rh(III)-catalyzed synthesis of isoquinolinones containing a C3 quaternary centre via a tandem C–H allylation/annulative Markovinkov addition reaction has been achieved. This method employing a single Rh(III) complex as the catalyst tolerated various functional groups, and was applicable to late-stage diversification of N-methoxyamides derived from steroids and adapalene. By applying the protocol as the key step, US28 inverse agonist analogs were conveniently synthesized.

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来源期刊

Organic Chemistry Frontiers

CiteScore: 7.8

自引率: 8.7%

年发文量: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Rh(iii)-Catalyzed C–H allylation/annulative Markovnikov addition with 5-methylene-1,3-dioxan-2-one: formation of isoquinolinones containing a C3 quaternary centre

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来源期刊

Organic Chemistry Frontiers

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