Synthesis of N-indolated amino acids or peptides from 2-alkynylanilines via a dearomatization process
文献信息
发布日期
2021-10-07
DOI
10.1039/D1QO01257F
影响因子
5.281
作者
Weilian Qiu, Weiyi Wang, Yin Liu, Renhua Fan
查看原文
摘要
A one-pot stepwise procedure for the synthesis of N-indolated amino acids or peptides from readily available 2-alkynylanilines was reported. The protocol involves the oxidative dearomatization of 2-alkynylanilines, the imino exchange with aliphatic amines, and subsequent cascade cyclization/nucleophilic addition/aromatization. The synthetic method might allow a rapid access to indolactam alkaloid derivatives.
期刊推荐
Biocatalysis and Biotransformation
Chinese Journal of Chemistry
Polycyclic Aromatic Compounds
Journal of Chemical Sciences
Critical Reviews in Solid State and Materials Sciences
Main Group Chemistry
Medicinal Chemistry Research
Herald of the Russian Academy of Sciences
Heteroatom Chemistry
NDT & E International
相关文献
Asymmetric organocatalytic double 1,6-addition: rapid access to chiral chromans with molecular complexity
Sourav Roy, Suman Pradhan, Krishan Kumar, Indranil Chatterjee
2020-04-28
Research Article
DOI: 10.1039/D0QO00354A
Synthesis and biological activity of dehydrophos derivatives
M. Mercedes Jiménez-Andreu, Francisco J. Sayago, Carlos Cativiela
2019-01-02
Paper
DOI: 10.1039/C8OB03079K
Iron catalysed selective reduction of esters to alcohols
Sem Raj Tamang, Anthony F. Cozzolino, Michael Findlater
2018-12-18
Communication
DOI: 10.1039/C8OB02661K
A hydrate salt-promoted reductive coupling reaction of nitrodienes with unactivated alkenes
Mengmeng Zhang, Liming Yang, Chao Tian, Meng Zhou, Guangming Li
2019-01-31
Paper
DOI: 10.1039/C9OB00136K
Chemiluminescence molecular probe with a linear chain reaction amplification mechanism
Samer Gnaim, Doron Shabat
2019-01-21
Communication
DOI: 10.1039/C8OB03042A
A metal-free visible-light-promoted phosphorylation/cyclization reaction in water towards 3-phosphorylated benzothiophenes
Xiao-Ya Yuan, Fan-Lin Zeng, Hu-Lin Zhu, Qi-Yan Lv, Xiao-Lan Chen, Lifen Peng, Bing Yu
2020-06-17
Research Article
DOI: 10.1039/D0QO00222D
Aromatization-driven deconstruction/refunctionalization of unstrained rings
Fangzhi Hu, Lubin Xu
2020-06-01
Highlight
DOI: 10.1039/D0QO00344A
Bicyclic acetals: biological relevance, scaffold analysis, and applications in diversity-oriented synthesis
Elena Lenci, Fernanda I. Saldívar-Gonzalez, José L. Medina-Franco
2018-12-19
Review Article
DOI: 10.1039/C8OB02808G
Iron-catalyzed asymmetric intramolecular cyclopropanation reactions using chiral tetramethyl-1,1′-spirobiindane-based bisoxazoline (TMSI-BOX) ligands
Haorui Gu, Shaoying Huang, Xufeng Lin
2019-01-09
Paper
DOI: 10.1039/C8OB03065K
您可能还喜欢
化合物问答
如何处理含有8-氯咪唑并[1,2-A]吡嗪(CAS号：69214-33-1)的废料？
处理含有8-氯咪唑并[1,2-A]吡嗪的废料时，应首先将其收集并进行化学回收或降解。如果无法回收，需采用安全的化学处理方法，如中和、氧化还原或沉淀。处理过程中需...
69214-33-18-chloroimidazo[1,2-...
化合物问答
Calhex 231 hydrochloride(CAS号：2387505-78-2)适用哪些法规指南？
Calhex 231 hydrochloride 需要遵循《全球化学品统一分类和标签制度》（GHS）的分类和标签要求，以及欧盟的《化学品注册、评估、授权和限制条...
2387505-78-24-Chloro-N-[(1S,2S)-...
化合物问答
11-Beta,17-alpha,21-三羟基-5-beta-孕烯-3,20-二酮(CAS号：1482-50-4)的物理化学性质是什么？
11-Beta,17-alpha,21-三羟基-5-beta-孕烯-3,20-二酮是一种无色结晶性粉末，分子量为372.45 g/mol。该化合物在水中的溶解度...
1482-50-45β-Dihydrocortisol
化合物问答
处理5-异丙基-1,3,4-恶二唑-2-羧酸(CAS号：944907-13-5)时应注意哪些实验室安全事项？
处理5-异丙基-1,3,4-恶二唑-2-羧酸时应注意以下安全事项：穿戴适当的个人防护装备，包括实验室外套、手套和护目镜；操作应在通风橱中进行，以减少吸入或接触有...
944907-13-55-Isopropyl-1,3,4-ox...
化合物问答
benzyl 3-bromopropanoate(CAS号：90841-55-7)安全吗？
Benzyl 3-bromopropanoate属于有毒物质，吸入、摄入或皮肤接触均可能对人体造成伤害。操作时应佩戴防护眼镜、口罩和手套，避免吸入蒸汽和直接接触...
90841-55-7Benzyl 3-bromopropan...
化合物问答
什么是(R)-N-苄氧羰基-3,4-二氢-1H-异喹啉羧酸(CAS号：151004-88-5)？
(R)-N-苄氧羰基-3,4-二氢-1H-异喹啉羧酸是一种含有苄氧羰基和异喹啉环结构的化合物，分子式为C17H15NO3。它是一种有机化合物，具有一定的生物活性...
151004-88-5(1R)-2-[(Benzyloxy)c...
化合物问答
在合成中是否有1-苄基吡啶嗡-3-羧酸盐(CAS号：15990-43-9)的替代品？
可以考虑使用1-苄基吡啶-3-羧酸盐作为1-苄基吡啶嗡-3-羧酸盐的替代品。此外，还可以探索其他类似物，如1-苄基吡啶-3-氨基甲酸酯等。具体的替代品选择需根据...
15990-43-91-Benzyl-3-pyridiniu...
化合物问答
(2,6-二甲基吡啶-3-基)甲醇(CAS号：582303-10-4)安全吗？
(2,6-二甲基吡啶-3-基)甲醇在使用时需注意安全，应避免吸入其蒸汽，接触皮肤和眼睛。操作应在通风良好的环境中进行，佩戴适当的个人防护装备。
582303-10-4(2,6-Dimethyl-3-pyri...
化合物问答
5-溴-2-乙烯基吡啶(CAS号：226883-52-9)的物理化学性质是什么？
5-溴-2-乙烯基吡啶是一种有机化合物，外观为白色固体，具有良好的结晶性。分子量约为190.03 g/mol。它的溶解性在水中较差，但在有机溶剂如二氯甲烷、甲醇...
226883-52-95-Bromo-2-vinylpyrid...
化合物问答
2-羟基-3-硝基-5-甲基吡啶(CAS号：7464-14-4)应用于哪些行业？
2-羟基-3-硝基-5-甲基吡啶主要应用于医药、聚合物和半导体行业。在医药领域，它可以用作合成其他药物的中间体。在聚合物领域，它可以作为功能性单体参与聚合反应，...
7464-14-45-Methyl-3-nitro-2(1...
来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
推荐化合物
推荐供应商
免责声明
本页面提供的学术期刊信息仅供参考和研究使用。我们与任何期刊出版商均无关联，也不处理投稿事宜。如有投稿相关咨询，请直接联系相关期刊出版商。
如发现页面信息有误，请发送邮件至 support@chemtradehub.com 联系我们。我们将及时核实并处理您的问题。