Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients
文献信息
Cloudius R. Sagandira, Sinazo Nqeketo, Kanyisile Mhlana, Thembela Sonti, Sibongiseni Gaqa, Paul Watts
Continuous flow chemistry has opened a new paradigm in both the laboratory and pharmaceutical industry. This review details the recently reported literature on continuous multistep telescoped synthesis of active pharmaceutical ingredients (APIs), inline flow downstream processing, in-process monitoring by process analytical technology (PAT) in flow, flow automation and artificial intelligence (AI) and robotics. We envisage that the integration of all these techniques can ensure an ‘ideal’ smart and efficient 21st century API chemical process that dramatically improves efficiency, agility, quality and flexibility in the manufacturing of pharmaceuticals.
相关文献
A computational study of the competing reaction mechanisms of the photo-catalytic reduction of CO2 on anatase(101)
Chung Man Ip, Alessandro Troisi
DOI: 10.1039/C6CP02642G
A robust salt-tolerant superoleophobic aerogel inspired by seaweed for efficient oil–water separation in marine environments
Yuqi Li, Hui Zhang, Jiandong Zhuang, Lihui Chen
DOI: 10.1039/C6CP04284H
New solvatochromic probes: performance enhancement via regulation of excited state structures
Qianshu Li, Gary J. Blanchard
DOI: 10.1039/C6CP04293G
Feynman force components: basis for a solution to the covalent vs. ionic dilemma
Justyna Dominikowska, Mirosław Jabłoński, Marcin Palusiak
DOI: 10.1039/C6CP03774G
Strong 1D localization and highly anisotropic electron–hole masses in heavy-halogen functionalized graphenes
Lukas Eugen Marsoner Steinkasserer, Alessandra Zarantonello, Beate Paulus
DOI: 10.1039/C6CP05188J
The study of electron transfer reactions in a dendrimeric assembly: proper utilization of dendrimer fluorescence
Somnath Koley, Subhadip Ghosh
DOI: 10.1039/C6CP05054A
pH-Responsive drug release and NIR-triggered singlet oxygen generation based on a multifunctional core–shell–shell structure
Renlu Han, Haopeng Yi, Junhui Shi, Zongjun Liu, Hao Wang, Yafei Hou, You Wang
DOI: 10.1039/C6CP05308D
Tuning thermal transport in Si nanowires by isotope engineering
Miquel Royo, Riccardo Rurali
DOI: 10.1039/C6CP04581B
The influence of mass-transport conditions on the ethanol oxidation reaction (EOR) mechanism of Pt/C electrocatalysts
Carsten Cremers
DOI: 10.1039/C6CP04294E
The effect of halide and iodate anions on the hydrogen-bonding network of water in aqueous nanodrops
Satrajit Chakrabarty, Evan R. Williams
DOI: 10.1039/C6CP05033F
您可能还喜欢
什么是2,6-二溴-4,8-双[(2-乙基己基)氧基]苯并[1,2-b:4,5-b']二噻吩(CAS号:1226782-13-3)?
2,6-二溴-4,8-双[(2-乙基己基)氧基]苯并[1,2-b:4,5-b']二噻吩是一种有机化合物,分子式为C23H32Br2O2S2。该化合物具有芳香性和...
木聚硫钠(CAS号:37319-17-8)的物理化学性质是什么?
木聚硫钠通常为无色或白色结晶性粉末,具有吸湿性。其分子量约为121.11 g/mol。木聚硫钠易溶于水,不溶于醇类和其他非极性溶剂。在酸性或碱性溶液中,木聚硫钠...
2-甲氧基-4-(三氟甲基)苄溴, JRD(CAS号:886500-59-0)适用哪些法规指南?
该化合物在合成、储存和运输过程中需遵循《全球化学品统一分类和标签制度》(GHS)的健康、环境和物理危险分类。在欧洲还需符合《化学品注册、评估、授权和限制》(RE...
1,4-Diazoniabicyclo[2.2.2]octane-1,4-disulfinate(CAS号:119752-83-9)的主要用途是什么?
1,4-二氮杂双环[2.2.2]辛烷-1,4-二硫酸二酯主要用于有机合成中的保护基团,特别是在保护胺基和硫醇基方面具有广泛应用。此外,它还用于一些特殊化学反应的...
如何处理含有4-(Bromomethyl)-2-fluorobenzenesulphonamide(CAS号:1645275-47-3)的废料?
含有4-(Bromomethyl)-2-fluorobenzenesulphonamide的废液应首先进行中和处理,以降低pH值,避免对环境造成腐蚀性影响。随后...
Loureiriol(CAS号:479195-44-3)的物理化学性质是什么?
Loureiriol是一种天然化合物,其分子式为C15H22O4。Loureiriol为无色结晶性粉末,具有较高的熔点和良好的热稳定性。其相对分子质量为262....
在合成中是否有3-氨基苯甲酰苯胺(CAS号:14315-16-3)的替代品?
在合成过程中,可以考虑使用类似结构的化合物作为3-氨基苯甲酰苯胺的替代品,例如N-苯基-3-氰基苯胺或N-苯基-3-硝基苯胺等,这些化合物具有相似的化学性质,可...
4-异氰酰苯基硼酸频哪醇酯(CAS号:380430-64-8)的市场或研究趋势如何?
4-异氰酰苯基硼酸频哪醇酯主要应用于有机合成、药物化学和材料科学领域。随着绿色化学的发展,该化合物因其高效的官能团转化能力和环境友好性而受到越来越多的关注。近年...
如何储存3β-乙酰氧基-7,25-甘遂二烯-24(R)-醇(CAS号:1352001-09-2)?
3β-乙酰氧基-7,25-甘遂二烯-24(R)-醇应储存在阴凉、干燥、通风良好的地方,避免直接光照。储存容器应密封,防止空气中的水分和氧气影响化合物的稳定性。建...
如何储存4-氟-2-甲基-1H-吲哚(CAS号:1260383-51-4)?
应将4-氟-2-甲基-1H-吲哚存放在阴凉、干燥、通风良好的地方,避免直接暴露在光照下。容器应密封,避免与空气中的水蒸气接触。建议在避光、温度不超过25℃的环境...
来源期刊
Reaction Chemistry & Engineering

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.










![6-(Benzyloxy)-8-(2-bromoacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one structure 6-(Benzyloxy)-8-(2-bromoacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one structure](https://cnstatic.chemtradehub.com/structs/926/926319-53-1-2287.webp)


![N-[2-(2-Pyridinyl)ethyl]-1-propanamine structure N-[2-(2-Pyridinyl)ethyl]-1-propanamine structure](https://cnstatic.chemtradehub.com/structs/554/55496-57-6-22b4.webp)
