Development of a gold nanoparticle-based lateral-flow strip for the detection of cannabidiol in functional beverages

文献信息

发布日期 2023-02-21

DOI 10.1039/D3AN00084B

影响因子 4.616

作者

Shuai Lv, Xinxin Xu, Lingling Guo, Liguang Xu, Liqiang Liu, Chuanlai Xu

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摘要

Cannabidiol (CBD), the most predominant cannabinoid, may cause addiction and liver damage. In this study, we synthesized a CBD hapten containing the carboxyl group of the spacer arm by derivatizing CBD. A highly specific and sensitive monoclonal antibody (mAb) was prepared with a half-maximal inhibitory concentration of 2.03 ng mL−1 and a limit of detection of 0.32 ng mL−1. MAb was highly specific for CBD. We developed an immunochromatographic assay (ICA) for the detection of CBD in functional beverages with a visible limit of detection of 100 ng mL−1 and a cut-off of 1000 ng mL−1. Compared with HPLC, ICA is more efficient and accurate and can be used for the rapid on-site detection of CBD in samples.

期刊推荐

Bulletin of the Chemical Society of Japan

Doklady Chemistry

Accounts of Chemical Research

AIAA Journal

Journal of the Chinese Chemical Society

Australian Journal of Chemistry

Chemical Reviews

Analyst

Corrosion Science

Advances in Colloid and Interface Science

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Development of a gold nanoparticle-based lateral-flow strip for the detection of cannabidiol in functional beverages

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