“Lighting up” fluoride: cellular imaging and zebrafish model interrogations using a simple ESIPT-based mycophenolic acid precursor-based probe
文献信息
发布日期
2023-05-15
DOI
10.1039/D3AN00646H
影响因子
4.616
作者
Neha Jain, Prasad M. Sonawane, Haoyan Liu, Arkaprava Roychaudhury, Youngseob Lee, Jongkeol An, Donghyeon Kim, Dongwook Kim, Yunsu Kim, Yeu-Chun Kim, Kyung-Bin Cho, Hee-Sung Park, Cheol-Hee Kim
查看原文
摘要
The discovery and implementation of media that derive from bioinspired designs and bear optical readouts featuring large Stokes shifts are of continued interest to a wide variety of researchers and clinicians. Myco-F, a novel mycophenolic acid precursor–based probe features a cleavable tert-butyldimethylsiloxy group to allow for fluoride detection. Myco-F exhibits high selectivity and specificity towards F− (Stokes shift = 120 nm). All measurements were performed in complete aqueous media (LOD=0.38 μM). Myco-F enables detection of fluoride ions in living HEK293 cells and localizes in the eye region (among other regions) of the zebrafish. DFT calculations support the proposed ESIPT working photomechanism.
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