Rhodium(iii)-catalyzed three-component C(sp2)–H activation for the synthesis of amines

文献信息

发布日期 2023-11-13
DOI 10.1039/D3CC04665F
影响因子 6.222
作者

Min Lin, Yu-Fei Wu, Zheng-Qiang Liu, Cheng Liang, Qing-Hua Li, Tang-Lin Liu


查看原文

摘要

Rhodium-catalyzed three-component C–H bond activation of aromatics with amides and aldehydes to synthesize amines was established. The addition of copper was found to be essential to ensure the high reactivity. The mechanistic studies indicated that key intermediates formed by the transmetallization between rhodium and copper could further promote the addition between 2-(pyridin-2-yl)-phenyl-metal species and imines. A series of densely substituted amines could be conveniently prepared by this one-step, three-component procedure from commercially available substrates via C–H bond activation with water as the only by-product.

相关文献

Molecular dynamics study on ions and water confined in the nanometer channel of Friedel's salt: structure, dynamics and interfacial interaction

Penggang Wang, Yuting Jia, Tao Li, Dongshuai Hou, Qi Zheng

2018-09-25 Paper

DOI: 10.1039/C8CP02450B

Back cover

Cover

DOI: 10.1039/C8CP91909G

Determination of band edges and their influences on photocatalytic reduction of nitrobenzene by bulk and exfoliated g-C3N4

Swapna Challagulla, Soumitra Payra, Chanchal Chakraborty, Sounak Roy

2019-01-17 Paper

DOI: 10.1039/C8CP06855K

Contents list

Front/Back Matter

DOI: 10.1039/C8CP91885F

A structural model of the hierarchical assembly of an amyloid nanosheet by an infrared probe technique

Baohuan Jia, Ying Sun, Lujuan Yang, Yang Yu, Haoran Fan, Gang Ma

2018-08-14 Paper

DOI: 10.1039/C8CP03003K

Tuning the oscillatory dynamics of the Belousov–Zhabotinsky reaction using ruthenium nanoparticle decorated graphene

D. Jaya Prasanna Kumar, Sachin Verma, Kabeer Jasuja, Pratyush Dayal

2019-01-16 Paper

DOI: 10.1039/C8CP06766J

Direct observation of atomic step edges on the rutile TiO2(110)-(1 × 1) surface using atomic force microscopy

Huan Fei Wen, Masato Miyazaki, Quanzhen Zhang, Yuuki Adachi, Yan Jun Li, Yasuhiro Sugawara

2018-10-18 Paper

DOI: 10.1039/C8CP06156D

Precise estimation of transfer free energies for ionic species between similar media

Carmen Esposito, Andreas Vitalis

2018-10-17 Paper

DOI: 10.1039/C8CP05331F

Back cover

Cover

DOI: 10.1039/C8CP91892A

Inside front cover

Cover

DOI: 10.1039/C8CP91884H

您可能还喜欢

化合物问答

2-(甲基磺酰基)嘧啶-5-胺(CAS号:56621-92-2)适用哪些法规指南?

该化合物适用的法规指南包括GHS(全球化学品统一分类和标签制度)分类为特定目标器官毒性-单次接触类别3;根据欧盟REACH法规,该化合物需要进行注册和评估;在美...

56621-92-22-(Methylsulfonyl)py...
化合物问答

在合成中是否有4-(4-氯苯基)-1H-咪唑(CAS号:35512-29-9)的替代品?

在合成中,可以考虑使用一些类似的化合物作为4-(4-氯苯基)-1H-咪唑的替代品,如4-(4-溴苯基)-1H-咪唑或4-(4-甲氧基苯基)-1H-咪唑。这些化合...

35512-29-94-(4-Chlorophenyl)-1...
化合物问答

什么是N~2~-甲基丙氨酸酰胺(CAS号:32012-16-1)?

N~2~-甲基丙氨酸酰胺是一种有机化合物,其化学名为2-(Methylamino)propanamide。它是一种酰胺类化合物,分子式为C4H10N2O,相对分...

32012-16-12-(Methylamino)propa...
化合物问答

如何处理含有N-苄基-3-氨基氧杂环丁烷草酸盐(CAS号:1956341-96-0)的废料?

处理含有N-苄基-3-氨基氧杂环丁烷草酸盐(CAS号:1956341-96-0)的废料时,应首先确保遵循相关法规要求,如GHS和REACH等。通常,废液应先进行...

1956341-96-0N-Benzyloxetan-3-ami...
化合物问答

4-bromo-2-chloro-6-methylbenzoic acid(CAS号:877149-07-0)的物理化学性质是什么?

4-溴-2-氯-6-甲基苯甲酸是一种固体化合物,具有较高的熔点和较低的沸点。它的分子量为261.03 g/mol。该化合物在水中几乎不溶,在有机溶剂中溶解度适中...

877149-07-04-Bromo-2-chloro-6-m...
化合物问答

2-[(2,5-二氯-4-嘧啶)氨基]-N-甲基苯甲酰胺(CAS号:761440-08-8)通常如何合成?

该化合物通常通过缩合反应合成,典型的方法是将2,5-二氯嘧啶与N-甲基苯甲酰胺在碱性条件下进行偶联反应。常用的碱包括NaH、LDA等强碱。该合成路线具有较高的选...

761440-08-82-[(2,5-dichloropyri...
化合物问答

1,4-二氯肽嗪(CAS号:4752-10-7)安全吗?

1,4-二氯肽嗪属于有毒化学物质,需要在通风良好的实验条件下操作。应避免吸入其粉尘或蒸汽,接触皮肤或眼睛。

4752-10-71,4-Dichlorophthalaz...
化合物问答

在合成中是否有3,5-二溴-4-甲基苯胺(CAS号:13194-73-5)的替代品?

3,5-二溴-4-甲基苯胺在某些合成路线中可能没有直接替代品。然而,在某些应用场景下,可以考虑使用其他类似结构的化合物如3,5-二溴-4-硝基苯胺或3,5-二碘...

13194-73-53,5-Dibromo-4-methyl...
化合物问答

2-氯喹啉-4-羧酸甲酯(CAS号:62482-26-2)的主要用途是什么?

2-氯喹啉-4-羧酸甲酯主要用于有机合成和药物合成领域,作为中间体或原料。它在合成某些药物和染料时具有重要作用。此外,该化合物还可能用于某些特定的化学研究中。

62482-26-2Methyl 2-chloro-4-qu...
化合物问答

i>]吡啶(CAS号:474708-88-8)安全吗?

6-溴-8-氯咪唑[1,2-a]吡啶在操作过程中需要谨慎以确保安全。该化合物具有一定的毒性,吸入其蒸气或粉尘可能导致呼吸道刺激。处理时应佩戴适当的防护装备,如手...

474708-88-86-Bromo-8-chloroimid...

来源期刊

Chemical Communications

Chemical Communications
CiteScore: 8.6
自引率: 4.7%
年发文量: 2458

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

推荐供应商

免责声明
本页面提供的学术期刊信息仅供参考和研究使用。我们与任何期刊出版商均无关联,也不处理投稿事宜。如有投稿相关咨询,请直接联系相关期刊出版商。
如发现页面信息有误,请发送邮件至 support@chemtradehub.com 联系我们。我们将及时核实并处理您的问题。