Total biosynthesis of fungal tetraketide pyrones
文献信息
发布日期
2023-10-23
DOI
10.1039/D3CC04758J
影响因子
6.222
作者
Yunlong Sun, Dongsong Tian, Eric Kuhnert, Geraldine Le Goff, Guillaume Arcile, Jamal Ouazzani, Russell J. Cox
查看原文
摘要
Fungal tetraketide pyrones possess important and potent bioactivities, but their detailed biosynthetic pathways are unknown and synthetic routes to their production are lengthy. Here we investigated the fungal pathways to the multiforisins and compounds related to islandic acid. Heterologous expression experiments yield high titres of these compounds and pathway intermediates. The results both elucidate the pathway and offer a platform for the total biosynthesis of this class of metabolites.
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来源期刊
Chemical Communications
CiteScore:
8.6
自引率:
4.7%
年发文量:
2458
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