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(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]heptanoic acid(CAS: 81093-37-0)
![(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]heptanoic acid](https://cnstatic.chemtradehub.com/structs/810/81093-37-0-265f.webp "(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]heptanoic acid")
CAS号
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基本信息
分子式
C23H36O7
分子量
424.53 g/mol
Physical Properties
熔点
171.2-173 °C
沸点
634.5°C at 760 mmHg
化学标识符
SMILES
CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)O)O)O)O
InChIKey
TUZYXOIXSAXUGO-PZAWKZKUSA-N
数据库引用
MDL号
MFCD00869375
常见问题
普伐他汀为白色或类白色结晶性粉末，无臭，无味。分子式为C25H38O5，分子量为426.56。普伐他汀在水中溶解度较低，在乙醇和甲醇中的溶解度较高。在酸性或碱性条件下，普伐他汀的稳定性较差，容易发生水解反应。
普伐他汀的合成通常采用生物合成和化学合成两种方法。化学合成方法中，常见的合成路线包括使用1-甲基-3-(3-羟基-2-氧代-2-丙基)-1H-吲哚-3-甲醇作为起始原料，通过多步反应，包括酰化、羟基保护、环化、还原等步骤，最终得到目标产物。生物合成方法则是利用工程改造的酵母或细菌表达特定的酶，通过发酵过程生产普伐他汀。
普伐他汀主要用于医药行业，作为降脂药物用于治疗高胆固醇血症和混合型血脂异常。此外，由于其独特的化学结构和生物活性，普伐他汀在研究领域也有一定的应用，例如作为研究工具分子进行药物筛选和生物化学研究。
在处理普伐他汀时，应佩戴个人防护装备（PPE），如实验服、手套和护目镜。操作应在通风橱中进行，以减少吸入或皮肤接触的风险。如果发生泄露，应立即清理，并使用大量水冲洗受影响区域。普伐他汀应储存在阴凉、干燥、通风良好的地方，远离火源和热源。处理过程中应遵循安全数据表（SDS）上的指导。
安全须知
使用前请验证产品规格和安全数据。联系供应商获取详细安全信息。
请始终遵循正确的操作程序
