化合物问答
普伐他汀(CAS号：81093-37-0)通常如何合成？
答案
![(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]heptanoic acid](https://cnstatic.chemtradehub.com/structs/810/81093-37-0-265f.webp "(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]heptanoic acid")
普伐他汀的合成通常采用生物合成和化学合成两种方法。化学合成方法中，常见的合成路线包括使用1-甲基-3-(3-羟基-2-氧代-2-丙基)-1H-吲哚-3-甲醇作为起始原料，通过多步反应，包括酰化、羟基保护、环化、还原等步骤，最终得到目标产物。生物合成方法则是利用工程改造的酵母或细菌表达特定的酶，通过发酵过程生产普伐他汀。
关于
CAS号
81093-37-0
英文名称
(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]heptanoic acid
中文名称
普伐他汀
分子式
C23H36O7
分子量
424.53 g/mol
SMILES
CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)O)O)O)O
InChIKey
TUZYXOIXSAXUGO-PZAWKZKUSA-N
最后更新: 2025-09-10 15:15
![(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]heptanoic acid — 湖北万得化工有限公司](https://cnstatic.chemtradehub.com/suppliers/67cecc352b2de6e8e95a5c3a/67cecc352b2de6e8e95a5c3a-logo.webp){kind=logo}
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