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(4R,12aS)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide(CAS: 1051375-16-6)
![(4R,12aS)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide](https://cnstatic.chemtradehub.com/structs/105/1051375-16-6-c5ba.webp "(4R,12aS)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide")
CAS号
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其他供应商提供的 (4R,12aS)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
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基本信息
分子式
C20H19F2N3O5
分子量
419.38 g/mol
Physical Properties
沸点
669.0±55.0°C at 760 mmHg
化学标识符
SMILES
C[C@@H]1CCO[C@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N12
InChIKey
RHWKPHLQXYSBKR-BMIGLBTASA-N
数据库引用
MDL号
MFCD20488027
常见问题
度鲁特韦是一种有机化合物，化学名称为(4R,12aS)-N-(2,4-二氟苯基)-7-羟基-4-甲基-6,8-二氧-3,4,6,8,12,12a-六氢-2H-吡啶并异吡唑啉环-9-羧酰胺。其分子结构包含一个吡啶并异吡唑啉环，通过引入2,4-二氟苯基和羟基等取代基，形成具有特定生物活性的羧酰胺类化合物。该物质作为抗病毒药物，主要用于抑制HIV病毒复制。
度鲁特韦是HIV蛋白酶抑制剂，属于抗逆转录病毒药物（ART），主要用于治疗人类免疫缺陷病毒（HIV）感染。其通过结合HIV蛋白酶活性位点，阻止病毒蛋白酶催化 gag 蛋白前体的加工，从而抑制病毒成熟和复制。通常与其他抗病毒药物（如洛匹那韦）联合使用，以降低耐药性风险并提高治疗效果。
度鲁特韦作为处方药，需在医生指导下使用。其安全性已通过临床试验验证，但可能伴随副作用，如腹泻、恶心、头痛及脂肪代谢异常。需注意药物相互作用，避免与强效CYP3A4抑制剂同用。孕妇及哺乳期妇女需权衡利弊后使用。操作时应佩戴防护手套和护目镜，防止皮肤接触或吸入。
度鲁特韦应储存于阴凉、干燥处，避免光照和高温。推荐保存温度为2-8℃（冷藏），相对湿度低于60%。需使用密封容器存放，防止受潮和污染。应远离热源和不相容物质（如强氧化剂），并置于儿童无法接触的专用柜中。药品开封后需注意保质期，按说明书要求处理过期样品。
安全须知
使用前请验证产品规格和安全数据。联系供应商获取详细安全信息。
请始终遵循正确的操作程序