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(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl 2-furoate(CAS: 397864-44-7)
![(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl 2-furoate](https://cnstatic.chemtradehub.com/structs/397/397864-44-7-6c02.webp "(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl 2-furoate")
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基本信息
分子式
C27H29F3O6S
分子量
538.58 g/mol
化学标识符
SMILES
CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)SCF)OC(=O)C5=CC=CO5)C)O)F)C)F
InChIKey
XTULMSXFIHGYFS-VLSRWLAYSA-N
数据库引用
MDL号
MFCD09954122
常见问题
糠酸氟替卡松-D5是一种白色至淡黄色结晶性粉末，分子量为621.72。它在水中溶解度较低，在有机溶剂中的溶解度会有所增加。该化合物具有良好的化学稳定性，但在强酸性或强碱性条件下可能会显示出一定的反应活性。
糠酸氟替卡松-D5通常通过甾体激素的合成路径，使用氯甲酸乙酯和氟化钠进行氟化反应，随后进行酯化反应制备得到。该过程通常需要使用有机溶剂，如二氯甲烷或乙醚，并在适当的温度下进行，产率可达80%以上。
糠酸氟替卡松-D5主要用于医药行业，作为吸入型糖皮质激素用于治疗哮喘和慢性阻塞性肺疾病。它也被应用于研究领域，以评估其药理学特性和生物分布特性。
在处理糠酸氟替卡松-D5时，应佩戴适当的个人防护装备，如手套、实验室外套和护目镜。操作应在通风橱内进行，以防止吸入或皮肤接触。如果发生泄漏，应立即用大量水清洗并通知实验室管理人员。安全数据表（SDS）对具体的安全操作提供了详细的指导。
安全须知
使用前请验证产品规格和安全数据。联系供应商获取详细安全信息。
请始终遵循正确的操作程序