化合物问答
IDO inhibitor 1(CAS号：1204669-37-3)通常如何合成？
答案
![N-(3-Bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide](https://cnstatic.chemtradehub.com/structs/120/1204669-37-3-3088.webp "N-(3-Bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide")
IDO inhibitor 1通常通过多步合成获得，首先合成中间体化合物，然后通过偶联反应和酰胺化反应最终得到目标化合物。具体步骤包括：1. 合成4-氨基-1,2,5-氧化三唑；2. 在酸性条件下与3-溴-4-氟苯胺进行偶联反应；3. 酰胺化反应生成最终的目标化合物。合成过程中使用了无机酸作为催化剂，产率约为70%。
关于
CAS号
1204669-37-3
英文名称
N-(3-Bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide
中文名称
IDO inhibitor 1
分子式
C11H13BrFN7O4S
分子量
438.24 g/mol
SMILES
c1cc(c(cc1N/C(=N\O)/c2c(non2)NCCNS(=O)(=O)N)Br)F
InChIKey
FBKMWOJEPMPVTQ-UHFFFAOYSA-N
最后更新: 2026-01-01 15:35
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