A simple kinetic model to describe the progression of prion disease

文献信息

发布日期 2001-09-24
DOI 10.1039/B104480J
影响因子 3.676
作者

V. Vitagliano, G. D'Errico


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摘要

A simple mathematical model based on bistationary autocatalytic kinetics is proposed to describe a possible progression of prion disease. The model accounts for both the sporadic and the infectious manifestation of the disease. Peculiarly, it shows how the disease grows if the concentration of the infectious agent (the prion PrPSc) is added to the metabolic system over a threshold concentration, while for a lower concentration the disease cannot grow.

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来源期刊

Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
自引率: 10.3%
年发文量: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

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