Identification of Candida tenuisxylose reductase as highly selective biocatalyst for the synthesis of aromatic α-hydroxyesters and improvement of its efficiency by protein engineering
文献信息
Regina Kratzer, Bernd Nidetzky
Wild-type Candida tenuisxylose reductase and two Trp-23 mutants thereof catalyze NADH-dependent reduction of a homologous series of aromatic α-keto esters with absolute pseudo re-face stereoselectivity and broad tolerance for the substituent on the aromatic ring, producing the corresponding R-alcohols in high yield.
期刊推荐

Journal of Enzyme inhibition and Medicinal Chemistry

Coloration Technology

Environmental Toxicology and Pharmacology

European Journal of Organic Chemistry

Contact Lens & Anterior Eye

Foundations of Chemistry

Mini-Reviews in Medicinal Chemistry

Advanced Engineering Materials

Current Pharmaceutical Biotechnology

CrystEngComm
相关文献
Alkaline salt-catalyzed aza Diels–Alder reactions of Danishefsky’s diene with imines in water under neutral conditions
Catherine Loncaric, Kei Manabe, Shū Kobayashi
DOI: 10.1039/B300880K
An unprecedented trans-oriented product from the cleavage of a dipeptide
Manas K. Saha, Ivan Bernal
DOI: 10.1039/B212587K
Titanium dipyrrolylmethane derivatives: rapid intermolecular alkyne hydroamination
Yanhui Shi, Christopher Hall, James T. Ciszewski, Changsheng Cao, Aaron L. Odom
DOI: 10.1039/B212423H
Isocyanide and biotin-derivatized Ag nanoparticles: an efficient molecular sensing mediator viasurface-enhanced Raman spectroscopy
Nam Hoon Kim, Seung Joon Lee, Kwan Kim
DOI: 10.1039/B300125C
Molecular tectonics: from enantiomerically pure sugars to enantiomerically pure triple stranded helical coordination network‡
Philippe Grosshans, Abdelaziz Jouaiti, Véronique Bulach, Jean-Marc Planeix, Mir Wais Hosseini, Jean-François Nicoud
DOI: 10.1039/B303238H
Via Ugi reactions to conformationally fixed cyclic peptides
DOI: 10.1039/B210952B
A distance-controlled oligopeptide linker as a novel photo-induced energy transfer switch by secondary structural transition
Akira Kishimoto, Toshiki Mutai, Koji Araki
DOI: 10.1039/B212851A
Transformation of a C-methylcalix[4]resorcinarene-based host–guest complex from a wave-like to a novel triangular brick-wall architecture
Bao-Qing Ma, Philip Coppens
DOI: 10.1039/B212548J
The preparation and structures of non-hydrocarbon functionalised fullerene–diamine adducts
Craig P. Butts, Mikael Jazdzyk
DOI: 10.1039/B303952H
New insight into a convenient base-promoted synthesis of Ru3(CO)12
Matthieu Fauré, Catherine Saccavini, Guy Lavigne
DOI: 10.1039/B303884J
您可能还喜欢
2-Bromo-4-chloro-1-(difluoromethyl)benzene(CAS号:1261476-50-9)的市场或研究趋势如何?
随着环保要求的提高和安全意识的增强,该化合物的研究和应用趋势正逐渐转向更安全、更环境友好的替代品。市场关注点主要集中在开发新型合成方法和绿色化学路径,以减少有害...
如何处理含有2,9 - 二苯基-1,10 - 菲罗啉(CAS号:25677-69-4)的废料?
处理含有2,9 - 二苯基 - 1,10 - 菲罗啉的废料时,应先将其收集在适当的容器中,避免与其他化学品混合。随后,可以通过水解或氧化等方法进行处理,直至达到...
处理(6-氯-吡嗪-3-基)-(4-乙基-哌嗪-1-基)-甲酮(CAS号:1178836-15-1)时应注意哪些实验室安全事项?
处理(6-氯-吡嗪-3-基)-(4-乙基-哌嗪-1-基)-甲酮时,应穿戴适当的个人防护装备(PPE),包括手套、护目镜和实验室外套。在通风橱中操作以确保良好的通...
处理(R)-2-氯-1-(2,4-二氯苯基)乙醇(CAS号:114446-57-0)时应注意哪些实验室安全事项?
在处理(R)-2-氯-1-(2,4-二氯苯基)乙醇时,应佩戴防护眼镜、实验室外套和手套,确保通风橱开启以减少接触和吸入的风险。避免直接接触皮肤和眼睛。处理过程中...
在合成中是否有3-氯-6-(3-氯哌啶-1-基)吡嗪(CAS号:1185310-37-5)的替代品?
可考虑使用类似结构的化合物作为替代品,如3-氯-6-(哌啶-1-基)吡嗪或3-氯-6-(2-氯哌啶-1-基)吡嗪,这些化合物在结构上与目标化合物相似,可能具有相...
苯并三氮唑-5-甲酸乙酯(CAS号:73605-91-1)通常如何合成?
该化合物可以通过乙酸乙酯与5-溴-1H-苯并三氮唑的反应合成,通常在无水条件下进行。合成过程中,需要使用适当的溶剂如乙酸乙酯,并在适当的温度下反应。该反应具有较...
什么是一水硫酸镁(CAS号:14168-73-1)?
一水硫酸镁是一种无机化合物,化学式为MgSO₄·H₂O,CAS号为14168-73-1。它由镁离子、硫酸根离子和一个结晶水分子组成,通常呈现为白色粉末或颗粒状固...
氘代-1,3-二氯-2-丙醇(CAS号:1173020-20-6)应用于哪些行业?
氘代-1,3-二氯-2-丙醇主要应用于医药和有机合成领域,作为研究化合物的氘代替代品,用于标记和追踪反应过程。此外,在聚合物和半导体生产中也有一定的应用潜力。
如何储存氰乙酸环己酯(CAS号:52688-11-6)?
氰乙酸环己酯应储存在阴凉、干燥、通风良好的环境中,远离火源和热源,防止阳光直射。储存容器应密封良好,避免与空气接触,防止发生不必要的反应。
2-碘-4-硝基苯胺(CAS号:6293-83-0)的市场或研究趋势如何?
目前,2-碘-4-硝基苯胺在医药和农药领域有一定的研究和应用,尤其是在开发新型药物和农药产品方面。然而,由于其潜在的环境和健康风险,行业正趋向于寻找更为安全和环...
来源期刊
Chemical Communications

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry


![5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]chromen-4-one structure 5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]chromen-4-one structure](https://cnstatic.chemtradehub.com/structs/191/1914963-20-4-2b05.webp)
![N-[(6-Bromo-3-pyridinyl)methyl]ethanamine structure N-[(6-Bromo-3-pyridinyl)methyl]ethanamine structure](https://cnstatic.chemtradehub.com/structs/120/120740-05-8-ca55.webp)
