A potential role for protein tyrosine phosphatase inhibition by a RuIII–edta complex (edta = ethylenediaminetetraacetate) in its biological activity
文献信息
发布日期
2008-05-28
DOI
10.1039/B803261K
影响因子
6.222
作者
Debabrata Chatterjee, Anannya Mitra, Aviva Levina, Peter A. Lay
查看原文
摘要
[RuIII(edta)(OH2/OH)]1−/2− (edta = ethylenediaminetetraacetate) inhibits protein tyrosine phosphatase (PTP) at physiological pH values in a mechanism that involves binding of the Cys residue of the catalytic domain of the enzyme and similar interactions may be important in the anti-cancer properties of the active forms of many Ru pro-drugs.
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来源期刊
Chemical Communications
CiteScore:
8.6
自引率:
4.7%
年发文量:
2458
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