Simple and efficient copper metal-mediated synthesis of alkoxyamine initiators
文献信息
发布日期
2011-05-27
DOI
10.1039/C1PY00131K
影响因子
5.582
作者
Simon Harrisson, Patrick Couvreur, Julien Nicolas
查看原文
摘要
A simple and efficient method is presented for the preparation of a wide range of alkoxyamines from nitroxide radicals and activated alkyl bromides at room temperature. The reaction requires a stoichiometric amount of copper metal (0.5 mol mol−1 alkyl bromide) and proceeds most rapidly in polar solvents such as acetonitrile, dimethyl sulfoxide or ethanol. No addition of copper(I) or copper(II) salts is necessary. Isolated yields of 71–94% were obtained across a range of alkyl bromide and nitroxide substrates, with reaction times of 1–16 h. The method is compatible with carboxylic acid and amine functionalities.
相关文献
Manganese-promoted reductive cross-coupling of disulfides with dialkyl carbonates
Chao-Peng Zhang, Tian-Zhang Wang, Yu-Feng Liang
2023-11-20
Communication
DOI: 10.1039/D3CC04862D
Hyperbranched polyphthalocyanine micelles with dual PTT/PDT functions for bacteria eradication under an NIR window
Ying Du, Guangyu Chu, Rui Yu, Rui Cui, Yuling Wang, Yiyong Mai, Ming Guan, Fugui Xu, Yongfeng Zhou
2023-11-01
Communication
DOI: 10.1039/D3CC04082H
Anion-encapsulating, discrete prism and extended frusta, from trimetallated triangular macrocycles and linkers
Hai-Ping Wang, Zhi-Gang Gu, Nathalie Gruber
2023-11-07
Communication
DOI: 10.1039/D3CC00137G
Prolonged near-infrared fluorescence imaging of microRNAs and proteases in vivo by aggregation-enhanced emission from DNA-AuNC nanomachines
Ting Wang, Kai Jiang, Yifan Wang, Limei Xu, Yingqi Liu, Shiling Zhang, Weiwei Xiong, Yemei Wang, Fenfen Zheng, Jun-Jie Zhu
2023-12-21
Edge Article
DOI: 10.1039/D3SC05887E
Thermally induced intermetallic Rh1Zn1 nanoparticles with high phase-purity for highly selective hydrogenation of acetylene
Xiaocheng Lan, Yu Wang, Boyang Liu, Zhenyu Kang, Tiefeng Wang
2023-12-23
Edge Article
DOI: 10.1039/D3SC05460H
Triazenide-supported [Cu4S] structural mimics of CuZ that mediate N2O disproportionation rather than reduction
Neal P. Mankad
2023-12-26
Edge Article
DOI: 10.1039/D3SC05451A
Rapid building block-economic synthesis of long, multi-O-GalNAcylated MUC5AC tandem repeat peptides
Arseniy Galashov, Ekaterina Kazakova, Christian E. Stieger, Oliver Seitz
2023-12-18
Edge Article
DOI: 10.1039/D3SC05006H
Simply accessible platinum(ii) complexes enabling alkene hydrosilylation at ppm catalyst loadings
Benon P. Maliszewski, Eleonora Casillo, Perrine Lambert, Catherine S. J. Cazin, Steven P. Nolan
2023-11-09
Communication
DOI: 10.1039/D3CC05033E
您可能还喜欢
化合物问答
2-(甲基磺酰基)嘧啶-5-胺(CAS号：56621-92-2)适用哪些法规指南？
该化合物适用的法规指南包括GHS（全球化学品统一分类和标签制度）分类为特定目标器官毒性-单次接触类别3；根据欧盟REACH法规，该化合物需要进行注册和评估；在美...
56621-92-22-(Methylsulfonyl)py...
化合物问答
在合成中是否有4-(4-氯苯基)-1H-咪唑(CAS号：35512-29-9)的替代品？
在合成中，可以考虑使用一些类似的化合物作为4-(4-氯苯基)-1H-咪唑的替代品，如4-(4-溴苯基)-1H-咪唑或4-(4-甲氧基苯基)-1H-咪唑。这些化合...
35512-29-94-(4-Chlorophenyl)-1...
化合物问答
什么是N~2~-甲基丙氨酸酰胺(CAS号：32012-16-1)？
N~2~-甲基丙氨酸酰胺是一种有机化合物，其化学名为2-(Methylamino)propanamide。它是一种酰胺类化合物，分子式为C4H10N2O，相对分...
32012-16-12-(Methylamino)propa...
化合物问答
如何处理含有N-苄基-3-氨基氧杂环丁烷草酸盐(CAS号：1956341-96-0)的废料？
处理含有N-苄基-3-氨基氧杂环丁烷草酸盐（CAS号：1956341-96-0）的废料时，应首先确保遵循相关法规要求，如GHS和REACH等。通常，废液应先进行...
1956341-96-0N-Benzyloxetan-3-ami...
化合物问答
4-bromo-2-chloro-6-methylbenzoic acid(CAS号：877149-07-0)的物理化学性质是什么？
4-溴-2-氯-6-甲基苯甲酸是一种固体化合物，具有较高的熔点和较低的沸点。它的分子量为261.03 g/mol。该化合物在水中几乎不溶，在有机溶剂中溶解度适中...
877149-07-04-Bromo-2-chloro-6-m...
化合物问答
2-[(2,5-二氯-4-嘧啶)氨基]-N-甲基苯甲酰胺(CAS号：761440-08-8)通常如何合成？
该化合物通常通过缩合反应合成，典型的方法是将2,5-二氯嘧啶与N-甲基苯甲酰胺在碱性条件下进行偶联反应。常用的碱包括NaH、LDA等强碱。该合成路线具有较高的选...
761440-08-82-[(2,5-dichloropyri...
4752-10-71,4-Dichlorophthalaz...
化合物问答
在合成中是否有3,5-二溴-4-甲基苯胺(CAS号：13194-73-5)的替代品？
3,5-二溴-4-甲基苯胺在某些合成路线中可能没有直接替代品。然而，在某些应用场景下，可以考虑使用其他类似结构的化合物如3,5-二溴-4-硝基苯胺或3,5-二碘...
13194-73-53,5-Dibromo-4-methyl...
化合物问答
2-氯喹啉-4-羧酸甲酯(CAS号：62482-26-2)的主要用途是什么？
2-氯喹啉-4-羧酸甲酯主要用于有机合成和药物合成领域，作为中间体或原料。它在合成某些药物和染料时具有重要作用。此外，该化合物还可能用于某些特定的化学研究中。
62482-26-2Methyl 2-chloro-4-qu...
化合物问答
i>]吡啶(CAS号：474708-88-8)安全吗？
6-溴-8-氯咪唑[1,2-a]吡啶在操作过程中需要谨慎以确保安全。该化合物具有一定的毒性，吸入其蒸气或粉尘可能导致呼吸道刺激。处理时应佩戴适当的防护装备，如手...
474708-88-86-Bromo-8-chloroimid...
来源期刊
Polymer Chemistry
CiteScore:
8.6
自引率:
7.3%
年发文量:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
推荐化合物
![1,1'-[(E)-1,2-Ethenediyl]bis(4-bromobenzene) structure](https://cnstatic.chemtradehub.com/structs/188/18869-30-2-c907.webp "1,1'-[(E)-1,2-Ethenediyl]bis(4-bromobenzene) structure")
![(3R)-3-(3-Fluorophenyl)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid structure](https://cnstatic.chemtradehub.com/structs/500/500789-04-8-20dd.webp "(3R)-3-(3-Fluorophenyl)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid structure")
推荐供应商
免责声明
本页面提供的学术期刊信息仅供参考和研究使用。我们与任何期刊出版商均无关联，也不处理投稿事宜。如有投稿相关咨询，请直接联系相关期刊出版商。
如发现页面信息有误，请发送邮件至 support@chemtradehub.com 联系我们。我们将及时核实并处理您的问题。