Synthesis of substituted amines and isoindolinones: catalytic reductive amination using abundantly available AlCl3/PMHS‡
文献信息
Vishal Kumar, Sushila Sharma, Upendra Sharma, Bikram Singh, Neeraj Kumar
AlCl3 has been employed for highly chemoselective reductive amination of carbonyl compounds in ethanol using polymethylhydrosiloxane as an inexpensive, stable and safe reducing agent without an inert atmosphere. A large range of functional groups such as nitro, carboxylic acid, acetyl, nitrile, halogen, methoxy, alkene and heterocycles were well tolerated. AlCl3 also catalyzed tandem amination–amidation of 2-carboxybenzaldehyde with different amines to afford N-substituted isoindolinones. The catalyst can be recycled at least three times without any significant effect on activity and selectivity.
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