Zebrafish assays as developmental toxicity indicators in the green design of TAML oxidation catalysts

文献信息

发布日期 2013-07-15
DOI 10.1039/C3GC40376A
影响因子 10.182
作者

Lisa Truong, Matthew A. DeNardo, Soumen Kundu, Terrence J. Collins, Robert L. Tanguay


查看原文

摘要

TAML activators promise a novel approach to water treatment by efficiently catalysing peroxide degradation of chemicals of high concern, including developmental toxicants. Seven TAML activators were subjected to zebrafish toxicity assays (1) to determine if developmental toxicity might be present to avoid in water treatment the very same problem that the catalysts have been designed to reduce/eliminate, and (2) to look for relationships between the structure, the known reactivity in peroxide catalysis and the toxicity. Differential toxicity within the studied TAML group and an interpretable design relationship have been revealed. Electron-withdrawing groups (EWGs) on the TAML macrocycle are known to increase the oxidative aggression of TAML/peroxide in the order Cl < CN < NO2 with the most reactive NO2-substituted catalysts being the most useful for degrading trace contaminants. The toxicity toward zebrafish was found to increase in the reverse order, NO2 < CN < Cl, the most positive possible result. While all the catalysts tested as possessing negligible toxicity at typical TAML/peroxide operating concentrations, three exhibited sufficient toxicity at higher concentrations to convey green design insight by indicating that these variants should be avoided in water treatment.

相关文献

Silver-catalyzed geminal aminofluorination of diazoketones with anilines and N-fluorobenzenesulphonimide

Jun Huang, Linyong Li, Haoguo Chen, Tiebo Xiao, Yuwei He, Lei Zhou

2017-01-12 Research Article

DOI: 10.1039/C6QO00813E

Visible light enabled γ-trifluoromethylation of Baylis–Hillman acetates: stereoselective synthesis of trisubstituted alkenes

Arvind Kumar Yadav, Anup Kumar Sharma, Krishna Nand Singh

2019-02-14 Research Article

DOI: 10.1039/C9QO00166B

A [3 + 2]–[4 + 2]–[3 + 2] cycloaddition sequence of isoquinolinium ylide

Ruzhang Liu, Rong-Guo Shi, Jing Sun, Chao-Guo Yan

2016-12-12 Research Article

DOI: 10.1039/C6QO00615A

Acid-promoted denitrogenative Pd-catalyzed addition of arylhydrazines with nitriles at room temperature

Kai Cheng, Guofang Wang, Mengting Meng, Chenze Qi

2016-12-13 Research Article

DOI: 10.1039/C6QO00634E

The impact of interplay between electronic and steric effects on the synthesis and the linear and non-linear optical properties of diketopyrrolopyrrole bearing benzofuran moieties

Anna Purc, Beata Koszarna, Irina Iachina, Daniel H. Friese, Mariusz Tasior, Krzysztof Sobczyk, Tomasz Pędziński, Jonathan Brewer, Daniel T. Gryko

2017-02-07 Research Article

DOI: 10.1039/C6QO00869K

AgNO3-catalyzed direct C–H arylation of quinolines by oxidative decarboxylation of aromatic carboxylic acids

Jin-Wei Yuan, Liang-Ru Yang, Pu Mao, Ling-Bo Qu

2016-12-05 Research Article

DOI: 10.1039/C6QO00533K

Synthesis, characterization and crystal structures of novel fluorinated di(thiazolyl)benzene derivatives

Maciej Barłóg, Ihor Kulai, Xiaozhou Ji, Nattamai Bhuvanesh, Somnath Dey, Eric Pierre Sliwinski, Hassan S. Bazzi, Lei Fang, Mohammed Al-Hashimi

2019-02-07 Research Article

DOI: 10.1039/C9QO00044E

Organocatalytic C–C bond activation of cyclopropenones for ring-opening formal [3 + 2] cycloaddition with isatins

Junyu Xu, Jing Cao, Chao Fang, Tao Lu, Ding Du

2017-01-16 Research Article

DOI: 10.1039/C6QO00734A

Synthesis of a [20]phenacene dodeca-ester by controlled condensation of seven naphthalene-based building blocks

Guillaume Naulet, Stéphanie Huet-Exiga, Harald Bock, Fabien Durola

2019-02-20 Research Article

DOI: 10.1039/C9QO00125E

Additive-free regio- and diastereoselective construction of fully-substituted isoxazolidines employing diazo compounds

Ekta Gupta, Mohd Khalid Zaheer, Ruchir Kant

2019-02-21 Research Article

DOI: 10.1039/C8QO01421C

您可能还喜欢

化合物问答

如何储存8-溴-4-羟基-6-(三氟甲氧基)喹啉-3-羧酸乙酯(CAS号:1072944-81-0)?

8-溴-4-羟基-6-(三氟甲氧基)喹啉-3-羧酸乙酯应储存在阴凉、干燥的地方,避免光照和高温。建议使用密封容器进行储存,以防止水分和空气的影响。

1072944-81-0Ethyl 8-bromo-4-hydr...
化合物问答

2,2-二(2-呋喃基)丙烷(CAS号:17920-88-6)的市场或研究趋势如何?

2,2-二(2-呋喃基)丙烷的研究趋势主要集中在新型材料的开发和应用,如高分子材料、有机光电材料等。市场趋势方面,随着环保要求的提高和新材料的应用,该化合物的需...

17920-88-62,2'-(2,2-Propanediy...
化合物问答

如何处理含有螺[呋喃并[3,4-b]吡啶-5(7H),4'-哌啶]-7-酮盐酸盐(CAS号:475152-31-9)的废料?

对于含有螺[呋喃并[3,4-b]吡啶-5(7H),4'-哌啶]-7-酮盐酸盐的废料,应首先进行分类和分离,以减少危险物质的数量。随后,可以考虑通过化学氧化、生物...

475152-31-97H-Spiro[furo[3,4-b]...
化合物问答

Cinnamyl 3-aminobut-2-enoate(CAS号:113898-97-8)安全吗?

Cinnamyl 3-氨基丁-2-烯酸在接触皮肤和眼睛时可能会引起刺激。应避免吸入其粉尘和烟雾。操作时应穿戴适当的个人防护装备,如手套、护目镜和实验室外套。

113898-97-8Cinnamyl 3-aminobut-...
化合物问答

反式-2-十二碳烯二酸(CAS号:6402-36-4)的市场或研究趋势如何?

反式-2-十二碳烯二酸在医药、材料科学等领域有一定的应用,但其市场相对较小。近年来,由于环保意识的提升,对环境友好型化学品的需求增加,研究倾向于开发更绿色的合成...

6402-36-4Traumatic Acid
化合物问答

什么是(9ci)-1H-苯并咪唑-5-乙酸(CAS号:473895-86-2)?

(9ci)-1H-苯并咪唑-5-乙酸是一种含氮杂环化合物,其化学结构为1H-苯并咪唑-5-乙酸。该化合物具有特定的分子式C8H7NO2,属于有机酸类化合物。

473895-86-21H-Benzimidazol-5-yl...
化合物问答

酞菁蓝(CAS号:147-14-8)的主要用途是什么?

酞菁蓝主要用作颜料和染料,广泛应用于塑料、油墨、涂料、纺织品及橡胶工业中。它也用于光敏材料,如太阳能电池和光刻胶。在医疗领域,酞菁蓝因其光敏特性被用于某些光动力...

147-14-8Copper(2+) phthalocy...
化合物问答

5-甲基-1,2,3,4-四氢异喹啉(CAS号:123593-99-7)安全吗?

5-甲基-1,2,3,4-四氢异喹啉在使用和储存时需要谨慎处理。它具有一定的毒性,应避免吸入其蒸气或直接接触皮肤和眼睛。操作此化合物时,建议佩戴防护眼镜、实验服...

123593-99-75-Methyl-1,2,3,4-tet...
化合物问答

如何处理含有3',4',5'-三甲氧基苯乙酮(CAS号:1136-86-3)的废料?

含有3',4',5'-三甲氧基苯乙酮的废液应首先确保其是否为危险废物,根据当地法规确定处理方法。通常,这类有机废液可以采用中和反应降低其pH值,然后通过蒸馏或萃...

1136-86-31-(3,4,5-Trimethoxyp...
化合物问答

如何储存KI-7(CAS号:1489263-00-4)?

KI-7应储存在通风良好的干燥环境中,避免光照和高温。建议使用密封容器储存,并保持在阴凉处。储存温度应控制在室温范围内,一般建议不超过25°C。避免与氧化剂接触...

1489263-00-42-(1-Benzyl-1H-indol...

来源期刊

Green Chemistry

Green Chemistry
CiteScore: 16.1
自引率: 7.5%
年发文量: 944

Green Chemistry provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on, but not limited to, the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998). Green chemistry is the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry is at the frontiers of this continuously-evolving interdisciplinary science and publishes research that attempts to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. Submissions on all aspects of research relating to the endeavour are welcome. The journal publishes original and significant cutting-edge research that is likely to be of wide general appeal. To be published, work must present a significant advance in green chemistry. Papers must contain a comparison with existing methods and demonstrate advantages over those methods before publication can be considered. For more information please see this Editorial. Coverage includes the following, but is not limited to: Design (e.g. biomimicry, design for degradation/recycling/reduced toxicity…) Reagents & Feedstocks (e.g. renewables, CO2, solvents, auxiliary agents, waste utilization…) Synthesis (e.g. organic, inorganic, synthetic biology…) Catalysis (e.g. homogeneous, heterogeneous, enzyme, whole cell…) Process (e.g. process design, intensification, separations, recycling, efficiency…) Energy (e.g. renewable energy, fuels, photovoltaics, fuel cells, energy storage, energy carriers…) Applications (e.g. electronics, dyes, consumer products, coatings, pharmaceuticals, preservatives, building materials, chemicals for industry/agriculture/mining…) Impact (e.g. safety, metrics, LCA, sustainability, (eco)toxicology…) Green chemistry is, by definition, a continuously-evolving frontier. Therefore, the inclusion of a particular material or technology does not, of itself, guarantee that a paper is suitable for the journal. To be suitable, the novel advance should have the potential for reduced environmental impact relative to the state of the art. Green Chemistry does not normally deal with research associated with 'end-of-pipe' or remediation issues.

推荐供应商

免责声明
本页面提供的学术期刊信息仅供参考和研究使用。我们与任何期刊出版商均无关联,也不处理投稿事宜。如有投稿相关咨询,请直接联系相关期刊出版商。
如发现页面信息有误,请发送邮件至 support@chemtradehub.com 联系我们。我们将及时核实并处理您的问题。