Chemically diverse polymer microarrays and high throughput surface characterisation: a method for discovery of materials for stem cell culture
文献信息
A. D. Celiz, J. G. W. Smith, A. K. Patel, R. Langer, D. G. Anderson, D. A. Barrett, L. E. Young, M. C. Davies, C. Denning, M. R. Alexander
Materials discovery provides the opportunity to identify novel materials that are tailored to complex biological environments by using combinatorial mixing of monomers to form large libraries of polymers as micro arrays. The materials discovery approach is predicated on the use of the largest chemical diversity possible, yet previous studies into human pluripotent stem cell (hPSC) response to polymer microarrays have been limited to 20 or so different monomer identities in each study. Here we show that it is possible to print and assess cell adhesion of 141 different monomers in a microarray format. This provides access to the largest chemical space to date, allowing us to meet the regenerative medicine challenge to provide scalable synthetic culture ware. This study identifies new materials suitable for hPSC expansion that could not have been predicted from previous knowledge of cell-material interactions.
期刊推荐

Bioorganic & Medicinal Chemistry

Journal of Asian Natural Products Research

Herald of the Russian Academy of Sciences

Journal of Chemical Sciences

Bioorganic & Medicinal Chemistry Letters

Chinese Journal of Chemistry

Atomization and Sprays

Journal of the Indian Institute of Science

NDT & E International

Biocatalysis and Biotransformation
相关文献
Symmetrisation schemes for global optimisation of atomic clusters
Mark T. Oakley, Roy L. Johnston, David J. Wales
DOI: 10.1039/C3CP44332A
Molecular dynamics simulations of wild type and mutants of human complement receptor 2 complexed with C3d
Hua Wan, Jian-ping Hu, Xu-hong Tian, Shan Chang
DOI: 10.1039/C2CP41388D
A RASSCF study of free base, magnesium and zinc porphyrins: accuracy versus efficiency‡
Andrew Kerridge
DOI: 10.1039/C2CP43982D
Effect of multilayer structure on cyclic performance of Si/Fe anode electrode in Lithium-ion secondary batteries
Hee-Kook Kang, Seong-Rae Lee, Won Il Cho, Byung Won Cho
DOI: 10.1039/C2CP42824E
A photoinduced charge transfer composite of graphene oxide and ferrocene
Subash Sharma, Koichi Wakita, Masayoshi Umeno, Yasuhiko Hayashi, Masaki Tanemura
DOI: 10.1039/C2CP43427J
Constrained density functional theory applied to electron tunnelling between defects in MgO
Jochen Blumberger, Keith P. McKenna
DOI: 10.1039/C2CP42537H
Structural prediction of a rhodamine-based biosensor and comparison with biophysical data
Martin R. Webb, John E. T. Corrie
DOI: 10.1039/C2CP42396K
A highly efficient light capturing 2D (nanosheet)–1D (nanorod) combined hierarchical ZnO nanostructure for efficient quantum dot sensitized solar cells
Heejin Kim, Kijung Yong
DOI: 10.1039/C2CP44045H
Directed electron transfer in Langmuir–Schäfer layers of porphyrin–fullerene and phthalocyanine–fullerene dyads in inverted organic solar cells
A. Tolkki, K. Kaunisto, A. Efimov, H. Kivistö, L. Storbacka, R. Savikoski, K. Huttunen, S. Lehtimäki, H. Lemmetyinen
DOI: 10.1039/C2CP24022J
您可能还喜欢
4-((4-甲基哌嗪-1-基)甲基)苯硼酸(CAS号:763120-62-3)的市场或研究趋势如何?
随着有机硼化学的发展,该化合物在催化、药物合成、材料科学等领域展现出潜在的应用价值。近年来,其在药物前体合成中的应用越来越受到关注。市场趋势显示,随着科研投入的...
如何储存2,4,5-三甲基-1-硝基苯(CAS号:610-91-3)?
2,4,5-三甲基-1-硝基苯应储存在阴凉、干燥且通风良好的地方,避免阳光直射。储存在密封的金属容器中,远离火源和热源。储存温度应控制在25°C以下,湿度不宜过...
处理2,5-二碘噻吩(CAS号:625-88-7)时应注意哪些实验室安全事项?
在处理2,5-二碘噻吩时,应穿戴适当的个人防护装备(PPE),包括实验室外套、手套和防护眼镜。在通风橱中进行操作以避免吸入蒸气。如果发生泄漏,应立即疏散人员并使...
在合成中是否有6-bromo-3-chloro-1H-indole(CAS号:57916-08-2)的替代品?
在合成6-溴-3-氯-1H-吲哚(CAS号:57916-08-2)时,可以考虑使用一些类似的化合物作为替代品,如6-氯-3-氯-1H-吲哚或3-氯-1H-吲哚,...
在合成中是否有(R)-(-)-1-(1-萘基)乙基异氰酸酯(CAS号:42340-98-7)的替代品?
可以考虑使用类似结构的化合物,如1-[(1R)-1-(2-氨基乙基)萘-1-基]乙基异氰酸酯作为替代品。此外,还可以寻找其他类型的异氰酸酯衍生物,如苯基异氰酸酯...
3-氨基苯甲酰苯胺(CAS号:14315-16-3)适用哪些法规指南?
3-氨基苯甲酰苯胺适用于多项法规指南,包括但不限于GHS(全球化学品统一分类和标签制度)分类为皮肤腐蚀/刺激类别2,以及潜在的皮肤过敏性类别1。在欧盟地区,它受...
β-环柠檬醛-D5(CAS号:26309-95-5)通常如何合成?
β-环柠檬醛-D5可通过不对称合成方法获得。常见的合成路线包括以环己酮为原料,经过选择性氧化、还原、保护基引入等步骤,最终得到目标化合物。该合成过程中通常使用多...
如何处理含有BIO-1211(CAS号:187735-94-0)的废料?
对于含有BIO-1211(CAS号:187735-94-0)的废料,首先应进行分类收集,确保符合环保要求。然后,可以考虑通过焚烧或其他专业处理方法进行处置。在处...
如何处理含有4-氯-2-氟-3-甲基苯酚(CAS号:1351668-24-0)的废料?
含有该化合物的废液应收集至专用容器中,避免与其他化学品混合。可采用焚烧或送交专业废弃物处理公司处理。处理过程中需遵守当地环保法规,确保不产生二次污染。处理前应进...
来源期刊
Biomaterials Science

Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions. Papers do not necessarily need to report a new biomaterial but should provide novel insight into the biological applications of the biomaterial. Articles that primarily focus on demonstrating novel materials chemistry and bring a molecular picture to bear on a given material’s suitability as a biomaterial are more suited to our companion journal, Journal of Materials Chemistry B. Biomaterials Science publishes primary research and review-type articles in the following areas: molecular design of biomaterials, including translation of emerging chemistries to biomaterials science of cells and materials at the nanoscale and microscale materials as model systems for stem cell and human biology materials for tissue engineering and regenerative medicine (Nano)materials and (nano)systems for therapeutic delivery interactions at the biointerface biologically inspired and biomimetic materials, including bio-inspired self-assembly systems and cell-inspired synthetic tools next-generation biomaterials tools and methods


![2,5-Furandione, dihydro-3-[3-(triethoxysilyl)propyl]- structure 2,5-Furandione, dihydro-3-[3-(triethoxysilyl)propyl]- structure](https://cnstatic.chemtradehub.com/structs/936/93642-68-3-3b4b.webp)
![(1S,2R,4S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol structure (1S,2R,4S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol structure](https://cnstatic.chemtradehub.com/structs/464/464-45-9-f88b.webp)
![N-[(9Z)-9-Octadecen-1-yl]-1,3-propanediamine structure N-[(9Z)-9-Octadecen-1-yl]-1,3-propanediamine structure](https://cnstatic.chemtradehub.com/structs/717/7173-62-8-d43e.webp)