An assessment of nanosponges for intravenous and oral drug delivery of BCS class IV drugs: Drug delivery kinetics and solubilization
文献信息
Kelly A. Gilmore
Polyester nanosponges were prepared with varied degrees of crosslinking densities of ∼4%, ∼7% and ∼10% and an average nanoscopic size of 100 nm. The crosslinking density and the influence towards the release kinetics of paclitaxel, a BCS class IV drug, for individual particles and a mixture of particles with two different crosslinking densities are investigated in buffer and gastrointestinal fluid to show fully adjustable release rates suitable for intravenous and oral delivery.
期刊推荐

European Journal of Wood and Wood Products

Science Progress

Journal of Physics and Chemistry of Solids

Proceedings of the National Academy of Sciences of the United States of America

Kinetics and Catalysis

Helvetica Chimica Acta

Journal of Organometallic Chemistry

Journal of Catalysis

Nature

Russian Chemical Reviews
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Polymer Chemistry

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.




