Heavy atom quenched coumarin probes for sensitive and selective detection of biothiols in living cells

文献信息

发布日期 2015-05-01

DOI 10.1039/C5AN00549C

影响因子 4.616

作者

Yuzhuo Ji, Qingqing Jin, Qingxiao Tong, Xinjing Tang

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摘要

A series of turn-on fluorescent probes with halogen acetyl amide at the 3-position of coumarin derivatives were synthesized. Fluorescence of these probes was efficiently quenched by heavy halogen atoms (Br and I, not Cl), which could be successfully used for selective detection of biothiols with the sensitivity of Cys > GSH > Hcy and much higher than thiol containing proteins. These represent the smallest fluorescence quenchers in designing fluorescent probes for detecting both endogenous and exogenous biothiols in living cells.

期刊推荐

Advanced Powder Technology

Cement and Concrete Composites

Synlett

Bio-Medical Materials and Engineering

Current Medicinal Chemistry

Advanced Composite Materials

Chirality

Diamond and Related Materials

Applied Composite Materials

Journal of Computer-Aided Molecular Design

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Heavy atom quenched coumarin probes for sensitive and selective detection of biothiols in living cells

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