IR and Raman imaging of murine brains from control and ApoE/LDLR−/− mice with advanced atherosclerosis

文献信息

发布日期 2016-06-08

DOI 10.1039/C6AN00107F

影响因子 4.616

作者

Karolina Chrabaszcz, Edyta Maslak, Katarzyna M. Marzec

查看原文

摘要

Confocal Raman mapping and FT-IR imaging combined with chemometric analysis was used to study the alterations in murine brain tissue induced by the development of atherosclerosis. FT-IR imaging allowed us to obtain lower spatial resolution data (∼5.5 μm) from large, representative cross-sectional brain areas, while Raman mapping provided a more detailed insight into chosen regions of interest with high spatial resolution (∼0.4 μm). A comparison of white (WM) and grey matter (GM) from control (C57BL/6J) and ApoE/LDLR−/− mice with advanced atherosclerosis revealed disease-induced changes in both: GM and WM. The alterations included an increased lipid to protein ratio and higher total content of cholesterol.

期刊推荐

Nature

Organic Preparations and Procedures International

Journal of Organometallic Chemistry

Helvetica Chimica Acta

Kinetics and Catalysis

Pure and Applied Chemistry

Journal of Physics and Chemistry of Solids

Russian Chemical Reviews

Science

Molecular Pharmacology

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

IR and Raman imaging of murine brains from control and ApoE/LDLR−/− mice with advanced atherosclerosis

文献信息

期刊推荐

相关文献

Water dissociation at MgO sub-monolayers on silver: a periodic model study

Photoinduced oxidation of [Mn(L)3]2+ and [Mn2O2(L)4]3+ (L = 2,2′-bipyridine and 4,4′-dimethyl-2,2′-bipyridine) with the [Ru(bpy)3]2+/-aryl diazonium salt system

Back cover

Allylic hydrogen abstraction II. H-abstraction from 1,4 type polyalkenes as a model for free radical trapping by polyunsaturated fatty acids (PUFAs)‡

Rate coefficients for the reaction of OH with (E)-2-pentenal, (E)-2-hexenal, and (E)-2-heptenal

On the role of interface polymers for the mechanics of natural polymeric composites

Endohedral clusterfullerenes—playing with cluster and cage sizes

Back matter

Electroactivity of a starburst hole-transport material in Langmuir–Blodgett films. Solid state effects and intervalence charge transfer

Mechanism for the conductivity changes caused by membrane electroporation of CHO cell-pellets‡

您可能还喜欢

十二烷基磺酸钠(CAS号：2386-53-0)的主要用途是什么？

5-羟基异喹啉(CAS号：2439-04-5)适用哪些法规指南？

在合成中是否有FIDAS-5 | Wnt(CAS号：1391934-98-7)的替代品？

(R)-tert-Butyl 2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylate(CAS号：1370600-56-8)通常如何合成？

处理4-(吡咯烷-1-基)环己酮(CAS号：10421-18-8)时应注意哪些实验室安全事项？

如何处理含有异麦芽糖醇(CAS号：534-73-6)的废料？

7-甲基壬酸(CAS号：41653-89-8)的主要用途是什么？

N-甲氧基-N-甲基甲基吡啶羧酰胺(CAS号：148493-07-6)应用于哪些行业？

什么是惕各酸香叶酯(CAS号：7785-33-3)？

1-环丁基哌嗪(CAS号：132800-13-6)安全吗？

来源期刊

Analyst

推荐化合物

4-(6-Formyl-2-pyridinyl)benzonitrile

(5beta)-17,21-Dihydroxypregnane-3,11,20-trione

4-[2-(3,4-Dihydro-2H-chromen-6-yl)-1,3-oxazol-5-yl]-1-(3-{[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl}benzyl)pyridinium bromide

2-Acetoxy-5-acetylbenzyl acetate

6-Chloro-1-benzofuran

推荐供应商