Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry

文献信息

发布日期 2016-03-15

DOI 10.1039/C6AN00617E

影响因子 4.616

作者

Cunyu Yan, Jason W. Schmidberger, Fabio Parmeggiani, Shaneela A. Hussain, Nicholas J. Turner, Sabine L. Flitsch, Perdita Barran

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摘要

The combination of stable isotope labelling with direct infusion ion mobility mass spectrometry (IM-MS) enabled qualitative and quantitative monitoring of biocatalytic reactions with reduced analysis times, enhanced sensitivity and μL-level assay volumes. The new approach was demonstrated by applying to both lipase and monooxygenase enzymes, including multi-substrate screening.

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来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry

文献信息

期刊推荐

相关文献

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An expeditive and green chemo-enzymatic route to diester sinapoyl-l-malate analogues: sustainable bioinspired and biosourced UV filters and molecular heaters

An efficient and chemoselective method to generate arynes‡

Mutual induced fit transition structure stabilization of corannulene's bowl-to-bowl inversion in a perylene bisimide cyclophane

A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase

Crystallographic evidence for global aromaticity in the di-anion and tetra-anion of a cyclophane hydrocarbon

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