DNA tetrahedron and star trigon nanostructures for target recycling detection of nucleic acid

文献信息

发布日期 2016-05-04

DOI 10.1039/C6AN00762G

影响因子 4.616

作者

Xifeng Chen, Bidou Wang, Guangxing Liu, Yuguo Tang, Peng Miao

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摘要

Human immunodeficiency virus (HIV) is a retrovirus which attacks the human body's immune system and further leads to acquired immunodeficiency syndrome (AIDS). Nucleic acid detection is of great importance in the medical diagnosis of such diseases. Herein, we develop a simple and enzyme-free electrochemical method for the target recycling detection of nuclei acid. DNA tetrahedron and star trigon nanostructures are designed and constructed on the electrode interface for target capture and signal enrichment. This strategy is convenient and sensitive, with a limit of detection as low as 1 fM, and can also successfully distinguish single-base mismatched DNA. Therefore, the proposed method has a promising potential application for HIV DNA detection.

期刊推荐

Saudi Pharmaceutical Journal

New Journal of Chemistry

Journal of Peptide Science

Russian Journal of General Chemistry

Crystallography Reports

Acta Materialia

Organic Process Research & Development

Chemistry Education Research and Practice

Russian Journal of Bioorganic Chemistry

Russian Chemical Bulletin

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

DNA tetrahedron and star trigon nanostructures for target recycling detection of nucleic acid

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