Molecular labels for analysis of amines and diols by spray based ionization-mass spectrometry

文献信息

发布日期 2016-06-22

DOI 10.1039/C6AN00907G

影响因子 4.616

作者

S. T. Ayrton, R. G. Cooks, M. Pugia

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摘要

A family of imidazolium and pyridinium salts was synthesized for the purpose of labeling amines and 1,2-diols for highly sensitivite analysis by mass spectrometry. The chosen mass labels are shown to serve as effective reporters when bound to particles functionalized with amines or 1,2-diols and the binding is reversible. The straightforward synthetic route allows analogous internal standards to be generated quickly. Solvents amenable to electrospray ionization facilitate the rapid liberation of imidazolium and pyridinium mass labels from particles by hydrolysis in aqueous acid, while the acetal bond remains stable in anhydrous or buffered aqueous solution. Detection of the labels is demonstrated at 1 nM and quantitation of mass labels released from particles is also demonstrated.

期刊推荐

Journal of Medicinal Chemistry

Journal of Heterocyclic Chemistry

Journal of Organometallic Chemistry

Molecular Pharmacology

Proceedings of the National Academy of Sciences of the United States of America

Fibre Chemistry

Russian Chemical Reviews

Pure and Applied Chemistry

Science Progress

Journal of Catalysis

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Molecular labels for analysis of amines and diols by spray based ionization-mass spectrometry

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