Retinol initiated poly(lactide)s: stability upon polymerization and nanoparticle preparation

文献信息

发布日期 2017-06-26

DOI 10.1039/C7PY00881C

影响因子 5.582

作者

Diana Kalden, Matthias Westerhausen

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摘要

The synthesis of retinol initiated polylactide (PLA) by ring opening polymerization (ROP) of L-lactide via in situ calcium alkoxide formation with all-trans-retinol and Ca[N(SiMe3)2]2(THF)2 is described. PLAs with degree of polymerization (DP) values ranging from 13 to 60 were obtained and characterized in detail by means of 1H nuclear magnetic resonance (NMR) spectroscopy, size exclusion chromatography (SEC), UV/vis spectroscopy and (tandem) mass spectrometry techniques. Stable nanoparticles (NPs) were prepared via a nanoprecipitation method and characterized by DLS and SEM. The stability of retinol upon conjugation to PLA as well as the nanoparticle formulation was investigated in detail and found to be significantly affected by the storage conditions such as exposure to light, oxygen and temperature.

期刊推荐

Science Progress

Russian Chemical Reviews

Proceedings of the National Academy of Sciences of the United States of America

Organic Preparations and Procedures International

Pharmacological Reviews

Journal of Catalysis

Fibre Chemistry

Journal of Organometallic Chemistry

Helvetica Chimica Acta

Molecular Pharmacology

来源期刊

Polymer Chemistry

CiteScore: 8.6

自引率: 7.3%

年发文量: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Retinol initiated poly(lactide)s: stability upon polymerization and nanoparticle preparation

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来源期刊

Polymer Chemistry

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