Glutathione-driven Cu(i)–O2 chemistry: a new light-up fluorescent assay for intracellular glutathione

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发布日期 2018-04-25

DOI 10.1039/C8AN00704G

影响因子 4.616

作者

Peng Fei Gao, Yu Ting Mao, Tong Yang, Hong Yan Zou, Yuan Fang Li

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摘要

Besides its widely known role as an endogenous antioxidant in scavenging free radicals, glutathione (GSH) can also play the role of prooxidant and promote CuO-induced formation of hydroxyl radicals to light up a fluorescent signal through Cu(I)–O2 chemistry without requiring additional H2O2. This approach is independent of the mechanisms of enzyme mimics, such as the well-known oxidase and peroxidase mimetics, providing a new method to simply and effectively analyze intracellular GSH.

期刊推荐

Israel Journal of Chemistry

Proceedings of the National Academy of Sciences of the United States of America

Helvetica Chimica Acta

Pure and Applied Chemistry

Kinetics and Catalysis

European Journal of Wood and Wood Products

Russian Chemical Reviews

Journal of Physics and Chemistry of Solids

Science

Journal of Medicinal Chemistry

来源期刊

Analyst

CiteScore: 7.8

自引率: 5.6%

年发文量: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Glutathione-driven Cu(i)–O2 chemistry: a new light-up fluorescent assay for intracellular glutathione

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