Tandem radical cyclization of N-methacryloyl benzamides with CBr4 to construct brominated isoquinolinediones
文献信息
Songhai Huang, Pengfei Niu, Yingpeng Su, Dongcheng Hu, Congde Huo
A simple cumene (isopropylbenzene, IPB) promoted auto-oxidation involved tandem radical cyclization of N-methacryloyl benzamides using stable and easy-to-handle CBr4 as the bromine source is described. This strategy provides an efficient and practical approach for the synthesis of bromine containing isoquinolinediones. This method also presents a new way to generate bromine radicals using a mild auto-oxidation pathway.
期刊推荐

Russian Journal of Organic Chemistry

Russian Journal of Coordination Chemistry

Russian Chemical Bulletin

Chemistry Education Research and Practice

Organic Process Research & Development

Crystallography Reports

Chemical Communications

Current Opinion in Solid State & Materials Science

New Journal of Chemistry

Nature Medicine
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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

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