Iron-catalyzed regioselective alkylation of 1,4-quinones and coumarins with functionalized alkyl bromides

文献信息

发布日期 2019-12-23

DOI 10.1039/C9OB02289A

影响因子 3.876

作者

Dengke Li, Xianfu Shen

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摘要

A simple and efficient Fe-catalyzed regioselective alkylation of 1,4-quinones and coumarins, using functionalized alkyl bromides as alkylating reagents, has been developed. The reaction proceeds under mild conditions with the addition of alkyl bromides to a wide range of 1,4-quinone and coumarin derivatives with a broad substrate scope and wide functional group tolerance to provide the products in good yields. Further application of these strategies could be extended to important biologically active antimalarial lead drugs, such as plasmodione on a gram scale in a single step for medicinal purposes.

期刊推荐

Journal of Saudi Chemical Society

Drug Discovery Today

Current Opinion in Solid State & Materials Science

New Journal of Chemistry

Organic Process Research & Development

Russian Chemical Bulletin

Russian Journal of Coordination Chemistry

Chemistry Education Research and Practice

Russian Journal of Organic Chemistry

Saudi Pharmaceutical Journal

来源期刊

Organic & Biomolecular Chemistry

CiteScore: 3.4

自引率: 10.3%

年发文量: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Iron-catalyzed regioselective alkylation of 1,4-quinones and coumarins with functionalized alkyl bromides

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Organic & Biomolecular Chemistry

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