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An efficient synthesis of fluoro-neplanocin A analogs using electrophilic fluorination and palladium-catalyzed dehydrosilylation
文献信息
发布日期
2019-02-12
DOI
10.1039/C9QO00099B
影响因子
5.281
作者
Dnyandev B. Jarhad, Min Hwan Jang, Young Sup Shin, Hong-Rae Kim, Young Eum Hyun, Ji-seong Yoon, Lak Shin Jeong
查看原文
摘要
Neplanocin A analogs have attracted attention in the fields of biological and medicinal chemistry due to their potent and broad-spectrum antiviral and antitumor activities. To further explore their potential as therapeutic agents, an alternative and efficient synthesis of fluoro-neplanocin A analogs has been developed by employing stereoselective electrophilic fluorination and palladium-catalyzed dehydrosilylation as key steps. With respect to previous syntheses, the present synthetic methodology provides easy access to key intermediates that could contribute to expanding further the structure–activity relationship studies of neplanocin A analogs.
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来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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