Synthesis and characterization of potential stereoisomeric and degradation impurities of ulipristal acetate

文献信息

发布日期 2019-02-08

DOI 10.1039/C9QO00144A

影响因子 5.281

作者

Bin Yu, Yongrui Tu, Yongqiang Sun, Wei Chen

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摘要

Ulipristal acetate (UPA) was developed by Laboratoire HRA Pharma, France and approved by the FDA for emergency contraception in August 2010. Though several methods have been developed for the synthesis of UPA, the steroidal impurities would appear inevitably and have not been reported in detail. In this work, several stereoisomeric and N,N-didemethylated impurities of UPA were analyzed and synthesized. The stereoisomers were obtained through an efficient and practical approach, and the structure of the key stereoisomer U-1 was confirmed by single-crystal X-ray analysis. Our research would be important and valuable for the quality control of UPA manufacturing.

期刊推荐

Organic Preparations and Procedures International

Helvetica Chimica Acta

Kinetics and Catalysis

Journal of Catalysis

Nature

European Journal of Wood and Wood Products

Pure and Applied Chemistry

Proceedings of the National Academy of Sciences of the United States of America

Journal of Physics and Chemistry of Solids

Molecular Pharmacology

来源期刊

Organic Chemistry Frontiers

CiteScore: 7.8

自引率: 8.7%

年发文量: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Synthesis and characterization of potential stereoisomeric and degradation impurities of ulipristal acetate

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