Spiroetherones A and B, sesquiterpene naphthoquinones, as angiogenesis inhibitors from the marine sponge Dysidea etheria
文献信息
发布日期
2019-12-09
DOI
10.1039/C9QO01346F
影响因子
5.281
作者
Wei-Hua Jiao, Qi-Hang Xu, Jie Cui, Ru-Yi Shang, Yun Zhang, Jia-Bao Sun, Qi Yang, Ke-Chun Liu, Hou-Wen Lin
查看原文
摘要
Spiroetherones A (1) and B (2), a pair of sesquiterpene naphthoquinones with an unprecedented “spiroetherane” carbon skeleton, were isolated from the marine sponge Dysidea etheria collected from the South China Sea. Their structures and absolute configurations were determined by spectroscopic analyses coupled with quantum chemistry DFT GIAO 13C NMR and ECD calculations. Spiroetherone A (1) showed anti-angiogenic activity in a zebrafish model with an IC50 value of 2.4 μM. In addition, the plausible biogenetic pathway of the two metabolites is proposed.
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来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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