Stereoselective synthetic strategies of stereogenic carbon centers featuring a difluoromethyl group

文献信息

发布日期 2021-03-15

DOI 10.1039/D1QO00032B

影响因子 5.281

作者

Fengyun Gao, Boyu Li, Yalan Wang, Qushuo Chen, Yongzhen Li, Kairong Wang, Wenjin Yan

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摘要

Difluoromethyl groups possess specific steric and electronic properties due to their slightly acidic C–H bonds and the natural characteristics of fluorine atoms, which allow them to act as chemically inert hydrogen-bond donors and then as surrogates in a wide assortment of important molecular recognition processes. As a result, the construction of chiral carbon centres bearing difluoromethyl groups is not only valuable for the synthesis of various fluorine-containing compounds, but also useful for the modulation of the properties of organic compounds in drug design. The scope of this review is to summarize routine asymmetric synthetic methods which enable the effective and selective introduction of difluoromethyl groups into the desired compounds.

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来源期刊

Organic Chemistry Frontiers

CiteScore: 7.8

自引率: 8.7%

年发文量: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Stereoselective synthetic strategies of stereogenic carbon centers featuring a difluoromethyl group

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