![N-[(Benzyloxy)carbonyl]serine structure](https://cnstatic.chemtradehub.com/structs/276/2768-56-1-77f7.webp "N-[(Benzyloxy)carbonyl]serine structure")
Intramolecular difunctionalization of methylenecyclopropanes tethered with carboxylic acid by visible-light photoredox catalysis
文献信息
发布日期
2021-06-15
DOI
10.1039/D1QO00564B
影响因子
5.281
作者
Hao-Zhao Wei, Yin Wei
查看原文
摘要
We have developed a visible-light photoredox catalyzed intramolecular difunctionalization of MCPs to access spiro[cyclopropane-1,2-indan]one from easily prepared methylenecyclopropanes tethered with carboxylic acid. The reaction can be performed under mild conditions, affording target products in excellent yields with a high atomic economy, and this cyclization reaction can be extended to gram scale synthesis. The products could be transformed to 1-indanone motifs existing in many natural products and bioactive compounds.
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来源期刊
Organic Chemistry Frontiers
CiteScore:
7.8
自引率:
8.7%
年发文量:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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