Diastereoselective construction of structurally diverse 2,3-dihydroquinolin-4-one scaffolds via redox neutral cascade [1,7]-hydride transfer/cyclization

文献信息

发布日期 2021-12-07

DOI 10.1039/D1QO01530C

影响因子 5.281

作者

Ronghao Xie, Shixiao Chen, Xianping Xiang, Xiangcong Yin, Lubin Xu, Shuai-Shuai Li, Liang Wang, Fengying Dong

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摘要

The pharmaceutically significant 2,3-dihydroquinolin-4-one scaffolds were constructed diastereoselectively and facilely via redox-neutral cascade Knoevengel condensation/[1,7]-hydride transfer/cyclization/transesterification in DCE from readily available methyl 2-aminobenzoacetate and diverse aldehydes, which features novel and highly valuable product structures, diastereoselective construction of all-carbon quaternary centers carrying allylic or propargyl groups as well as a privileged 3-spirocyclic 3,4-dihydrocoumarin moiety, an unusual pattern of [1,7]-hydride transfer, broad substrate scope, etc.

期刊推荐

Acta Metallurgica Sinica-English Letters

Critical Reviews in Solid State and Materials Sciences

Atomization and Sprays

Medicinal Chemistry Research

Colloid Journal

Biocatalysis and Biotransformation

Journal of the Indian Institute of Science

Topics in Catalysis

Bioorganic & Medicinal Chemistry Letters

Cellulose

来源期刊

Organic Chemistry Frontiers

CiteScore: 7.8

自引率: 8.7%

年发文量: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Diastereoselective construction of structurally diverse 2,3-dihydroquinolin-4-one scaffolds via redox neutral cascade [1,7]-hydride transfer/cyclization

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